Structure function relationships of immunostimulatory polysaccharides: A review

被引：806

作者：

Ferreira, Sonia S. ^{[1
]}

Passos, Claudia P. ^{[1
]}

Madureira, Pedro ^{[2
,3
,4
]}

Vilanova, Manuel ^{[2
,3
,4
]}

Coimbra, Manuel A. ^{[1
]}

机构：

[1] Univ Aveiro, Dept Chem, QOPNA, P-3810193 Aveiro, Portugal

[2] Univ Porto, Inst Invest & Inovacao Saude, P-4200135 Oporto, Portugal

[3] Univ Porto, IBMC, P-4150180 Oporto, Portugal

[4] Univ Porto, ICBAS, P-4050313 Oporto, Portugal

来源：

CARBOHYDRATE POLYMERS | 2015年 / 132卷

关键词：

Immunomodulation; Triple helix; Branching; Acetylation; Sulfation; Glucans; MACROPHAGE IMMUNOMODULATORY ACTIVITY; WATER-SOLUBLE POLYSACCHARIDE; GRAECUM L. GALACTOMANNAN; MALIAN MEDICINAL-PLANT; MOLECULAR-WEIGHT; IMMUNOLOGICAL ACTIVITIES; PECTIC POLYSACCHARIDES; ANTITUMOR-ACTIVITY; ALOE-VERA; IMMUNOBIOLOGICAL ACTIVITY;

D O I：

10.1016/j.carbpol.2015.05.079

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Immunostimulatory polysaccharides are compounds capable of interacting with the immune system and enhance specific mechanisms of the host response. Glucans, mannans, pectic polysaccharides, ara-binogalactans, fucoidans, galactans, hyaluronans, fructans, and xylans are polysaccharides with reported immunostimulatory activity. The structural features that have been related with such activity are the monosaccharide and glycosidic-linkage composition, conformation, molecular weight, functional groups, and branching characteristics. However, the establishment of structure-function relationships is possible only if purified and characterized polysaccharides are used and selective structural modifications performed. Aiming at contributing to the definition of the structure-function relationships necessary to design immunostimulatory polysaccharides with potential for preventive or therapeutical purposes or to be recognized as health-improving ingredients in functional foods, this review introduces basic immunological concepts required to understand the mechanisms that rule the potential claimed immuno stimulatory activity of polysaccharides and critically presents a literature survey on the structural features of the polysaccharides and reported immunostimulatory activity. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：378 / 396

页数：19

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