Substrate Specificity of the Macrolide-Glycosylating Enzyme Pair DesVII/DesVIII: Opportunities, Limitations, and Mechanistic Hypotheses

被引：61

作者：

Borisova, SA

Zhang, CS

Takahashi, H

Zhang, H

Wong, AW

Thorson, JS

Liu, HW ^{[1
]}

机构：

[1] Univ Texas, Coll Pharm, Div Med Chem, Austin, TX 78712 USA

[2] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

[3] Univ Wisconsin, Lab Biosynth Chem, Madison, WI 53705 USA

[4] Univ Wisconsin, Sch Pharm, Pharmaceut Sci Div, Natl Cooperat Drug Discovery Grp, Madison, WI 53705 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 17期

关键词：

antibiotics; biosynthesis; carbohydrates; glycosylation; macrolides;

D O I：

10.1002/anie.200503195

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Two's Company: DesVII, a glycosyltransferase involved in the biosynthesis of macrolide antibiotics, is unusual in that it requires an additional protein partner, DesVIII, for its full activity. The level of substrate tolerance of the DesVII/DesVIII pair was explored. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：2748 / 2753

页数：6

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