Cu-catalyzed N-arylation of oxazolidinones:: An efficient synthesis of the k-opioid receptor agonist CJ-15161

被引：35

作者：

Ghosh, A ^{[1
]}

Sieser, JE ^{[1
]}

Caron, S ^{[1
]}

Couturier, M ^{[1
]}

Dupont-Gaudet, K ^{[1
]}

Girardin, M ^{[1
]}

机构：

[1] Pfizer Inc, Global Res & Dev, Chem Res & Dev, Groton, CT 06340 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 03期

关键词：

D O I：

10.1021/jo052060z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for intermolecular N-arylation of oxazolidinones using catalytic copper in the presence of a bidentate ligand is reported. The conditions allow the use of copper and can be used to prepare enantiopure N-aryl β-amino alcohols. A short, scalable synthesis of CJ-15,161 is also reported. The required amines were obtained from the precursor α-amino acids or, more conveniently, from the corresponding 1,2-amino alcohols. © 2006 American Chemical Society.

引用

页码：1258 / 1261

页数：4

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