DNA Topoisomerases as Targets for Antiprotozoal Therapy

被引：25

作者：

Bakshi, R. P.

Shapiro, T. A. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Med, Div Clin Pharmacol, Baltimore, MD 21205 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 06期

基金：

美国国家卫生研究院;

关键词：

DNA topoisomerase; antiparasitic; poison; inhibitor; Trypanosoma; Plasmodium; Leishmania; protozoa;

D O I：

10.2174/1389557033487863

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Diseases caused by parasitic protozoa present a health problem of immense magnitude, and there is an urgent need for safe and effective new therapies. DNA topoisomerases are clinically relevant targets for anticancer and anti-bacterial agents. Inhibitor studies on parasite topoisomerases have revealed that these enzymes have great promise as molecular targets for anti-parasitics, and have helped to dissect the basic biology of DNA topoisomerases in these organisms. This review provides a brief introduction to DNA topoisomerases and anti-topoisomerase drugs, and an overview of studies on protozoal DNA topoisomerases and their inhibitors.

引用

收藏

页码：597 / 608

页数：12

相关论文

共 108 条

[1] Functional and regulatory characteristics of eukaryotic type II DNA topoisomerase [J].

Bakshi, RP ;

Galande, S ;

Muniyappa, K .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2001, 36 (01) :1-37

[2] A type IB topoisomerase with DNA repair activities [J].

Belova, GI ;

Prasad, R ;

Kozyavkin, SA ;

Lake, JA ;

Wilson, SH ;

Slesarev, AI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (11) :6015-6020

[3]

Bodley A. L, 2003, P NATL ACAD IN PRESS

[4] ANTITRYPANOSOMAL ACTIVITY OF CAMPTOTHECIN ANALOGS - STRUCTURE-ACTIVITY CORRELATIONS [J].

BODLEY, AL ;

WANI, MC ;

WALL, ME ;

SHAPIRO, TA .

BIOCHEMICAL PHARMACOLOGY, 1995, 50 (07) :937-942

[5] MOLECULAR AND CYTOTOXIC EFFECTS OF CAMPTOTHECIN, A TOPOISOMERASE-I INHIBITOR, ON TRYPANOSOMES AND LEISHMANIA [J].

BODLEY, AL ;

SHAPIRO, TA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (09) :3726-3730

[6] Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum [J].

Bodley, AL ;

Cumming, JN ;

Shapiro, TA .

BIOCHEMICAL PHARMACOLOGY, 1998, 55 (05) :709-711

[7] INHIBITION OF TYPE-II TOPOISOMERASE BY FOSTRIECIN [J].

BORITZKI, TJ ;

WOLFARD, TS ;

BESSERER, JA ;

JACKSON, RC ;

FRY, DW .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (21) :4063-4068

[8] Characterization of a Leishmania donovani gene encoding a protein that closely resembles a type IB topoisomerase [J].

Broccoli, S ;

Marquis, JF ;

Papadopoulou, B ;

Olivier, M ;

Drolet, M .

NUCLEIC ACIDS RESEARCH, 1999, 27 (13) :2745-2752

[9] Topoisomerases in kinetoplastids [J].

Burri, C ;

Bodley, AL ;

Shapiro, TA .

PARASITOLOGY TODAY, 1996, 12 (06) :226-231

[10] MODE OF ACTION OF PENTAVALENT ANTIMONIALS - SPECIFIC-INHIBITION OF TYPE-I DNA TOPOISOMERASE OF LEISHMANIA-DONOVANI [J].

CHAKRABORTY, AK ;

MAJUMDER, HK .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 152 (02) :605-611

← 1 2 3 4 5 6 7 8 9 10 →