Mechanism of cytokine modulation of epithelial tight junction barrier

被引：507

作者：

Al-Sadi, Rana ^{[1
]}

Boivin, Michel ^{[1
]}

Ma, Thomas ^{[1
,2
]}

机构：

[1] Univ New Mexico, Sch Med, Dept Internal Med, Mail Stop Code 10 5550, Albuquerque, NM 87131 USA

[2] Albuquerque Vet Affairs Med Ctr, Albuquerque, NM 87108 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2009年 / 14卷

关键词：

Tight Junctions; Cytokines; Intestinal Epithelial Cells; Barrier Function; Inflammation; Review; TUMOR-NECROSIS-FACTOR; INFLAMMATORY-BOWEL-DISEASE; TOTAL PARENTERAL-NUTRITION; EPIDERMAL-GROWTH-FACTOR; CACO-2 CELL MONOLAYERS; ALPHA TNF-ALPHA; NF-KAPPA-B; INTERFERON-GAMMA; IFN-GAMMA; INTESTINAL PERMEABILITY;

D O I：

10.2741/3413

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytokines play a crucial role in the modulation of inflammatory response in the gastrointestinal tract. Pro-inflammatory cytokines including tumor necrosis factor-alpha, interferon-gamma, interleukin-1 beta (IL-1 beta), and interleukin-12 are essential in mediating the inflammatory response, while anti-inflammatory cytokines including interleukin-10 and transforming growth factor-beta are important in the attenuation or containment of inflammatory process. It is increasingly recognized that cytokines have an important physiological and pathological effect on intestinal tight junction (TJ) barrier. Consistent with their known pro-inflammatory activities, pro-inflammatory cytokines cause a disturbance in intestinal TJ barrier, allowing increased tissue penetration of luminal antigens. Recent studies indicate that the inhibition of cytokine induced increase in intestinal TJ permeability has an important protective effect against intestinal mucosal damage and development of intestinal inflammation. In this review, the effects of various pro-inflammatory and anti-inflammatory cytokines on intestinal TJ barrier and the progress into the mechanisms that mediate the cytokine modulation of intestinal TJ barrier are reviewed.

引用

页码：2765 / 2778

页数：14

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