The inverse relationship between serum high-density lipoprotein cholesterol level and all-cause mortality in a 9.6-year follow-up study in the Japanese general population

被引:110
作者
Okamura, T [1 ]
Hayakawa, T
Kadowaki, T
Kita, Y
Okayama, A
Ueshima, H
机构
[1] Shiga Univ Med Sci, Dept Hlth Sci, Otsu, Shiga 5202192, Japan
[2] Shimane Univ, Sch Med, Dept Publ Hlth, Matsue, Shimane, Japan
[3] Natl Cardiovasc Ctr, Dept Prevent Cardiol, Osaka, Japan
关键词
high-density lipoprotein cholesterol; mortality; cohort studies; risk factors;
D O I
10.1016/j.atherosclerosis.2005.03.042
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In populations with higher high-density lipoprotein cholesterol (HDL-C) levels and lower coronary mortality than Western populations, such as in Japan, the beneficial effect of HDL-C on all-cause mortality may be different. Furthermore, prior studies have not focused on very high level of HDL-C. A total of 7175 community Japanese residents without a past history of cardiovascular disease in 300 randomly selected districts were followed for 9.6 years. During follow-up, there were 636 deaths. The multivariate adjusted hazard ratio (HR) of HDL-C for all-cause or cause-specific mortality was calculated using a Cox proportional hazard model adjusted for other cardiovascular risk factors. The all-cause mortality suggested an inverse, graded relation with HDL-C categories; HR for the very high HDL-C category (>= 1.82 mmol/L), compared with the reference group (1.04-1.55 mmol/L), was 0.73 (95% confidence interval, C.I., 0.50-1.06) for men, 0.63 (95% C.I., 0.41-0.94) for women and 0.70 (95% C.I., 0.53-0.93) when men and women were combined. Serum HDL-C as a continuous variable showed a significant inverse association with all-cause mortality. The cardiovascular mortality indicated a non-significant but inverse graded relation with HDL-C categories. As in the many Western populations, serum HDL-C levels were inversely associated with all-cause mortality in the Japanese general population. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:143 / 150
页数:8
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