A visual approach to proteomics

被引：177

作者：

Nickell, S ^{[1
]}

Kofler, C ^{[1
]}

Leis, AP ^{[1
]}

Baumeister, W ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Biol Struct, D-82152 Martinsried, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 03期

关键词：

D O I：

10.1038/nrm1861

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cryo-electron tomography is an emerging imaging technique that has unique potential for molecular cell biology. At the present resolution of 4 - 5 nm, large supramolecular structures can be studied in unperturbed cellular environments and, in the future, it will become possible to map molecular landscapes inside cells in a more comprehensive manner. 'Visual proteomics' aims to complement and extend mass-spectrometry-based inventories, and to provide a quantitative description of the macromolecular interactions that underlie cellular functions.

引用

页码：225 / 230

页数：6

共 52 条

[1] Mass spectrometry-based proteomics
Aebersold, R
Mann, M
[J]. NATURE, 2003, 422 (6928) : 198 - 207
[2] Biological ultrastructure research; the first 50 years\
Afzelius, BA
Maunsbach, AB
[J]. TISSUE & CELL, 2004, 36 (02) : 83 - 94
[3] Cryo-electron microscopy of vitreous sections
Al-Amoudi, A
Chang, JJ
Leforestier, A
McDowall, A
Salamin, LM
Norlén, LPO
Richter, K
Blanc, NS
Studer, D
Dubochet, J
[J]. EMBO JOURNAL, 2004, 23 (18) : 3583 - 3588
[4] Structure-based systems biology: a zoom lens for the cell
Aloy, P
Russell, RB
[J]. FEBS LETTERS, 2005, 579 (08) : 1854 - 1858
[5] Portrait of a molecule
Ball, P
[J]. NATURE, 2003, 421 (6921) : 421 - 422
[6] From proteomic inventory to architecture
Baumeister, W
[J]. FEBS LETTERS, 2005, 579 (04) : 933 - 937
[7] Nuclear pore complex structure and dynamics revealed by cryoelectron tomography
Beck, M
Förster, F
Ecke, M
Plitzko, JM
Melchior, F
Gerisch, G
Baumeister, W
Medalia, O
[J]. SCIENCE, 2004, 306 (5700) : 1387 - 1390
[8] Toward detecting and identifying macromolecules in a cellular context:: Template matching applied to electron tomograms
Böhm, J
Frangakis, AS
Hegerl, R
Nickell, S
Typke, D
Baumeister, W
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (26) : 14245 - 14250
[9] INVERSION OF FAN-BEAM SCANS IN RADIO ASTRONOMY
BRACEWELL, RN
RIDDLE, AC
[J]. ASTROPHYSICAL JOURNAL, 1967, 150 (2P1) : 427 - +
[10] COMPLETE VITRIFICATION IN PURE LIQUID WATER AND DILUTE AQUEOUS-SOLUTIONS
BRUGGELLER, P
MAYER, E
[J]. NATURE, 1980, 288 (5791) : 569 - 571

← 1 2 3 4 5 6 →