DNA methylation profiling in the clinic: applications and challenges

被引：585

作者：

Heyn, Holger ^{[1
]}

Esteller, Manel ^{[1
,2
,3
]}

机构：

[1] Bellvitge Biomed Res Inst IDIBELL, Canc Epigenet & Biol Program PEBC, Barcelona 08908, Catalonia, Spain

[2] Univ Barcelona, Sch Med, Dept Physiol Sci 2, E-08036 Barcelona, Catalonia, Spain

[3] ICREA, Barcelona 08010, Catalonia, Spain

来源：

NATURE REVIEWS GENETICS | 2012年 / 13卷 / 10期

基金：

欧洲研究理事会;

关键词：

CPG ISLAND HYPERMETHYLATION; SUBEROYLANILIDE HYDROXAMIC ACID; HISTONE DEACETYLASE INHIBITOR; POLYMERASE-CHAIN-REACTION; PROSTATE-CANCER PATIENTS; PROMOTER HYPERMETHYLATION; HIGH-THROUGHPUT; COLORECTAL-CANCER; EPIGENETIC MODIFICATIONS; GSTP1; METHYLATION;

D O I：

10.1038/nrg3270

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Knowledge of epigenetic alterations in disease is rapidly increasing owing to the development of genome-wide techniques for their identification. The ever-growing number of genes that show epigenetic alterations in disease emphasizes the crucial role of these epigenetic alterations - particularly DNA methylation - for future diagnosis, prognosis and prediction of response to therapies. This Review focuses on epigenetic profiling, which has started to be of clinical value in cancer and may in the future be extended to other diseases, such as neurological and autoimmune disorders.

引用

页码：679 / 692

页数：14

共 139 条

[41] Molecular origins of cancer: Epigenetics in cancer [J].

Esteller, Manel .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (11) :1148-1159

[42] Epigenetic gene silencing in cancer: the DNA hypermethylome [J].

Esteller, Manel .

HUMAN MOLECULAR GENETICS, 2007, 16 :R50-R59

[43] Metallothionein 1E is methylated in malignant melanoma and increases sensitivity to cisplatin-induced apoptosis [J].

Faller, William J. ;

Rafferty, Mairin ;

Hegarty, Shauna ;

Gremel, Gabriela ;

Ryan, Denise ;

Fraga, Mario F. ;

Esteller, Manel ;

Dervan, Peter A. ;

Gallagher, William M. .

MELANOMA RESEARCH, 2010, 20 (05) :392-400

[44] Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant [J].

Fan, Meiyun ;

Yan, Pearlly S. ;

Hartman-Frey, Cori ;

Chen, Lei ;

Paik, Henry ;

Oyer, Samuel L. ;

Salisbury, Jonathan D. ;

Cheng, Alfred S. L. ;

Li, Lang ;

Abbosh, Phillip H. ;

Huang, Tim H-M. ;

Nephew, Kenneth P. .

CANCER RESEARCH, 2006, 66 (24) :11954-11966

[45] Breast Cancer Methylomes Establish an Epigenomic Foundation for Metastasis [J].

Fang, Fang ;

Turcan, Sevin ;

Rimner, Andreas ;

Kaufman, Andrew ;

Giri, Dilip ;

Morris, Luc G. T. ;

Shen, Ronglai ;

Seshan, Venkatraman ;

Mo, Qianxing ;

Heguy, Adriana ;

Baylin, Stephen B. ;

Ahuja, Nita ;

Viale, Agnes ;

Massague, Joan ;

Norton, Larry ;

Vahdat, Linda T. ;

Moynahan, Mary Ellen ;

Chan, Timothy A. .

SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (75)

[46] Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors [J].

Feber, Andrew ;

Wilson, Gareth A. ;

Zhang, Lu ;

Presneau, Nadege ;

Idowu, Bernadine ;

Down, Thomas A. ;

Rakyan, Vardhman K. ;

Noon, Luke A. ;

Lloyd, Alison C. ;

Stupka, Elia ;

Schiza, Vassia ;

Teschendorff, Andrew E. ;

Schroth, Gary P. ;

Flanagan, Adrienne ;

Beck, Stephan .

GENOME RESEARCH, 2011, 21 (04) :515-524

[47] Phenotypic plasticity and the epigenetics of human disease [J].

Feinberg, Andrew P. .

NATURE, 2007, 447 (7143) :433-440

[48] A DNA methylation fingerprint of 1628 human samples [J].

Fernandez, Agustin F. ;

Assenov, Yassen ;

Ignacio Martin-Subero, Jose ;

Balint, Balazs ;

Siebert, Reiner ;

Taniguchi, Hiroaki ;

Yamamoto, Hiroyuki ;

Hidalgo, Manuel ;

Tan, Aik-Choon ;

Galm, Oliver ;

Ferrer, Isidre ;

Sanchez-Cespedes, Montse ;

Villanueva, Alberto ;

Carmona, Javier ;

Sanchez-Mut, Jose V. ;

Berdasco, Maria ;

Moreno, Victor ;

Capella, Gabriel ;

Monk, David ;

Ballestar, Esteban ;

Ropero, Santiago ;

Martinez, Ramon ;

Sanchez-Carbayo, Marta ;

Prosper, Felipe ;

Agirre, Xabier ;

Fraga, Mario F. ;

Grana, Osvaldo ;

Perez-Jurado, Luis ;

Mora, Jaume ;

Puig, Susana ;

Prat, Jaime ;

Badimon, Lina ;

Puca, Annibale A. ;

Meltzer, Stephen J. ;

Lengauer, Thomas ;

Bridgewater, John ;

Bock, Christoph ;

Esteller, Manel .

GENOME RESEARCH, 2012, 22 (02) :407-419

[49] Aberrant methylation in the promoter region of the reduced folate carrier gene is a potential mechanism of resistance to methotrexate in primary central nervous system lymphomas [J].

Ferreri, AJM ;

Dell'Oro, S ;

Capello, D ;

Ponzoni, M ;

Iuzzolino, P ;

Rossi, D ;

Pasini, F ;

Ambrosetti, A ;

Orvieto, E ;

Ferrarese, F ;

Arrigoni, G ;

Foppoli, M ;

Reni, M ;

Gaidano, G .

BRITISH JOURNAL OF HAEMATOLOGY, 2004, 126 (05) :657-664

[50] Selective inhibition of BET bromodomains [J].

Filippakopoulos, Panagis ;

Qi, Jun ;

Picaud, Sarah ;

Shen, Yao ;

Smith, William B. ;

Fedorov, Oleg ;

Morse, Elizabeth M. ;

Keates, Tracey ;

Hickman, Tyler T. ;

Felletar, Ildiko ;

Philpott, Martin ;

Munro, Shonagh ;

McKeown, Michael R. ;

Wang, Yuchuan ;

Christie, Amanda L. ;

West, Nathan ;

Cameron, Michael J. ;

Schwartz, Brian ;

Heightman, Tom D. ;

La Thangue, Nicholas ;

French, Christopher A. ;

Wiest, Olaf ;

Kung, Andrew L. ;

Knapp, Stefan ;

Bradner, James E. .

NATURE, 2010, 468 (7327) :1067-1073

← 1 2 3 4 5 6 7 8 9 10 →