pH-Sensitive Polydopamine Nanocapsules for Cell Imaging and Drug Delivery Based on Folate Receptor Targeting

被引：82

作者：

Cheng, Fang-Fang ^{[1
]}

Zhang, Jing-Jing ^{[1
]}

Xu, Fang ^{[1
]}

Hu, Li-Hui ^{[1
]}

Abdel-Halim, E. S. ^{[2
]}

Zhu, Jun-Jie ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 100871, Jiangsu, Peoples R China

[2] King Saud Univ, Coll Sci, Dept Chem, Petrochem Res Chair, Riyadh 11451, Saudi Arabia

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2013年 / 9卷 / 07期

关键词：

Polydopamine Nanocapsules; pH-Responsive; Cell Imaging; Drug Delivery; Endocytosis; MAGNETIC NANOPARTICLES; SILICA NANOPARTICLES; MEDIATED DELIVERY; SUSTAINED-RELEASE; SURFACE; FUNCTIONALIZATION; IMMOBILIZATION; MICROCAPSULES; ENCAPSULATION; DOXORUBICIN;

D O I：

10.1166/jbn.2013.1611

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

A pH-triggered drug delivery system that can specially target to folate-receptors-overexpressing cancer cells was designed based on newly developed polydopamine capsules and folic acid. The polycapsules bioconjugates possess capabilities of high drug loading, enhanced folate-receptor-mediated cell uptake, and sustained drug release by intracellular pH changes. It was also found that the sustained release of drugs significantly increased reactive oxygen species (ROS) level in targeted cells. The efficient cell-specific endocytosis and intracellular pH-responsive controlled drug delivery of the capsules is promising for future in vivo therapeutic applications.

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收藏

页码：1155 / 1163

页数：9

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