pH-responsive polymeric carrier encapsulated magnetic nanoparticles for cancer targeted imaging and delivery

被引：45

作者：

Chen, Dongyun ^{[1
]}

Xia, Xuewei ^{[1
]}

Gu, Hongwei ^{[1
]}

Xu, Qingfeng ^{[1
]}

Ge, Jianfeng ^{[1
]}

Li, Yonggang ^{[2
]}

Li, Najun ^{[1
]}

Lu, Jianmei ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Absorbent Mat & Tech Environm, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Dept Radiol, Suzhou 215006, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2011年 / 21卷 / 34期

基金：

中国国家自然科学基金;

关键词：

IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; BLOCK-COPOLYMERS; MICELLES; FOLATE; EFFICIENT; PRODRUG; DESIGN;

D O I：

10.1039/c1jm11195g

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Multifunctional drug delivery systems with favorable compatibility, high selectivity and efficiency are appropriate candidates for future medical applications. For this purpose, a multifunctional nanocomposite that enables selective magnetic resonance imaging and anticancer therapy by encapsulating hydrophobic superparamagnetic nanoparticles and chemotherapeutic agent doxorubicin with a novel biodegradable pH-activated polymeric carrier was synthesized. The as-synthesized amphiphilic polymer has excellent biocompatibility and pH-responsivity. The obtained nanocomposites selectively release the encapsulated drug and magnetic nanoparticles in mildly acidic endosomal/lysosomal compartments due to the degradation of the pH-responsive bonds, resulting in a change of imaging signal and cancer therapy. Furthermore, when compared with the nanocomposites without a targeting moiety, as studied from over-expression of the folic acid receptor tumor cell culturing, the conjugates with folic acid showed a significantly more potent targeting capability.

引用

页码：12682 / 12690

页数：9

共 46 条

[1]

Responsive polymers in controlled drug delivery [J].