Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G

被引：59

作者：

Lane, Jonathan W.

Estevez, Alberto

Mortara, Kyle

Callan, Ondine

Spencer, Jeffrey R.

Williams, Robert M. ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

[2] Univ Colorado, Ctr Canc, Aurora, CO 80045 USA

[3] Celera Genom, San Francisco, CA 94080 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 12期

关键词：

renieramycin G; 3-epi-renieramycin G; jorumycin; 3-epi-jorumycin; antitumor agents; tetrahydroisoquinolines;

D O I：

10.1016/j.bmcl.2006.03.042

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analogues of the tetrahydroisoquinoline family of antitumor antibiotics, 3-epi-jorumycin (3) and 3-epi-renieramycin G (4), in addition to their respective parent natural products (-)-jorumycin (1) and (-)-renieramycin G (2) were evaluated against both human colon (HCT-116) and human lung (A549) cancer cell lines. (-)-Jorumycin (1) displayed potent growth inhibition with GI(50) values in the low nanomolar range (1.9-24.3 nM), while compounds 2-4 were found to be substantially less cytotoxic (GI(50) 0.6-14.0 mu M). (c) 2006 Elsevier Ltd. All rights reserved.

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页码：3180 / 3183

页数：4

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