Synthesis and photophysical characterization of new fluorescent bis-amino acids bearing a heterocyclic bridge containing benzoxazole and thiophene

被引：35

作者：

Costa, Susana P. G. ^{[1
]}

Batista, Rosa M. F. ^{[1
]}

Raposo, M. Manuela M. ^{[1
]}

机构：

[1] Univ Minho, Ctr Chem, P-4710057 Braga, Portugal

来源：

TETRAHEDRON | 2008年 / 64卷 / 41期

关键词：

bis-amino acids; (oligo)thiophene; benzoxazole; fluorescence; fluorescent probes; bis-alanines;

D O I：

10.1016/j.tet.2008.07.096

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new bis-alanine derivatives bearing (oligo)thiophene and benzoxazole units as the hetero-aromatic bridge were synthesized in moderate to good yields. The photophysical characterization of these bis-amino acids was performed by UV-vis absorption and fluorescence emission studies and revealed that the compounds displayed exceptionally high fluorescence quantum yields, making them good candidates for application as fluorescent probes when incorporated into peptides, as well as peptide conformation-restricting and cross-linking elements. (C) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：9733 / 9737

页数：5

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