Diastereoselective Oxidative Carbon-Carbon Bond Formation via Silyl Bis-enol Ethers

被引：54

作者：

Avetta, Christopher T., Jr. ^{[1
]}

Konkol, Leah C. ^{[1
]}

Taylor, Carla N. ^{[1
]}

Dugan, Karen C. ^{[1
]}

Stern, Charlotte L. ^{[1
]}

Thomson, Regan J. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 24期

关键词：

D O I：

10.1021/ol802516z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diisopropylsilyl bis-enol ethers are shown to be powerful intermediates for the diastereoselective dimerization and cross-coupling of cyclic ketones. The trends observed for the oxidative coupling of a range of different dialkylsilyl bis-enol ethers derived from cyclohexanone are rationalized by invoking a stereochemical model based on a Thorpe-Ingold effect.

引用

页码：5621 / 5624

页数：4

共 24 条

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