Regulatory nascent peptides in the ribosomal tunnel

被引：191

作者：

Tenson, T

Ehrenberg, M

机构：

[1] Univ Tartu, Inst Mol & Cell Biol, Tartu, Estonia

[2] Uppsala Univ, BMC, ICM, S-75124 Uppsala, Sweden

来源：

CELL | 2002年 / 108卷 / 05期

关键词：

D O I：

10.1016/S0092-8674(02)00669-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accumulating evidence for nascent-peptide-mediated regulation of translation suggests that all nascent peptides do not necessarily interact with the ribosome In a similar manner. Recent studies have helped to elucidate the exit route of the nascent chain and its interactions with the ribosome.

引用

收藏

页码：591 / 594

页数：4

相关论文

共 20 条

[1] Architecture of the protein-conducting channel associated with the translating 80S ribosome [J].

Beckmann, R ;

Spahn, CMT ;

Eswar, N ;

Helmers, J ;

Penczek, PA ;

Sali, A ;

Frank, J ;

Blobel, G .

CELL, 2001, 107 (03) :361-372

[2] Flexibility of the nascent polypeptide chain within the ribosome - Contacts from the peptide N-terminus to a specific region of the 30S subunit [J].

Choi, KM ;

Atkins, JF ;

Gesteland, RF ;

Brimacombe, R .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 255 (02) :409-413

[3] A newly synthesized, ribosome-bound polypeptide chain adopts conformations dissimilar from early in vitro refolding intermediates [J].

Clark, PL ;

King, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (27) :25411-25420

[4] The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22 [J].

Gabashvili, IS ;

Gregory, ST ;

Valle, M ;

Grassucci, R ;

Worbs, M ;

Wahl, MC ;

Dahlberg, AE ;

Frank, J .

MOLECULAR CELL, 2001, 8 (01) :181-188

[5]

Hardesty B, 2001, PROG NUCLEIC ACID RE, V66, P41

[6] High resolution structure of the large ribosomal subunit from a mesophilic Eubacterium [J].

Harms, J ;

Schluenzen, F ;

Zarivach, R ;

Bashan, A ;

Gat, S ;

Agmon, I ;

Bartels, H ;

Franceschi, F ;

Yonath, A .

CELL, 2001, 107 (05) :679-688

[7] The signal recognition particle [J].

Keenan, RJ ;

Freymann, DM ;

Stroud, RM ;

Walter, P .

ANNUAL REVIEW OF BIOCHEMISTRY, 2001, 70 :755-775

[8]

Komar AA, 1997, J BIOL CHEM, V272, P10646

[9] Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration [J].

Liao, SR ;

Lin, JL ;

Do, H ;

Johnson, AE .

CELL, 1997, 90 (01) :31-41

[10] Ribosome regulation by the nascent peptide [J].

Lovett, PS ;

Rogers, EJ .

MICROBIOLOGICAL REVIEWS, 1996, 60 (02) :366-+