Regulatory nascent peptides in the ribosomal tunnel

被引:191
作者
Tenson, T
Ehrenberg, M
机构
[1] Univ Tartu, Inst Mol & Cell Biol, Tartu, Estonia
[2] Uppsala Univ, BMC, ICM, S-75124 Uppsala, Sweden
关键词
D O I
10.1016/S0092-8674(02)00669-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Accumulating evidence for nascent-peptide-mediated regulation of translation suggests that all nascent peptides do not necessarily interact with the ribosome In a similar manner. Recent studies have helped to elucidate the exit route of the nascent chain and its interactions with the ribosome.
引用
收藏
页码:591 / 594
页数:4
相关论文
共 20 条
[11]   The structure of ribosome-channel complexes engaged in protein translocation [J].
Ménétret, JF ;
Neuhof, A ;
Morgan, DG ;
Plath, K ;
Radermacher, M ;
Rapoport, TA ;
Akey, CW .
MOLECULAR CELL, 2000, 6 (05) :1219-1232
[12]   Upstream open reading frames as regulators of mRNA translation [J].
Morris, DR ;
Geballe, AP .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (23) :8635-8642
[13]   The ribosomal exit tunnel functions as a discriminating gate [J].
Nakatogawa, H ;
Ito, K .
CELL, 2002, 108 (05) :629-636
[14]   The structural basis of ribosome activity in peptide bond synthesis [J].
Nissen, P ;
Hansen, J ;
Ban, N ;
Moore, PB ;
Steitz, TA .
SCIENCE, 2000, 289 (5481) :920-930
[15]   Ribosome exchange revisited: a mechanism for translation-coupled ribosome detachment from the ER membrane [J].
Potter, MD ;
Seiser, RM ;
Nicchitta, CV .
TRENDS IN CELL BIOLOGY, 2001, 11 (03) :112-115
[16]   Ribosome structure and the mechanism of translation [J].
Ramakrishnan, V .
CELL, 2002, 108 (04) :557-572
[17]  
Richardson JP., 1996, ESCHERICHIA COLI SAL, V1, P822
[18]   Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria [J].
Schlünzen, F ;
Zarivach, R ;
Harms, J ;
Bashan, A ;
Tocilj, A ;
Albrecht, R ;
Yonath, A ;
Franceschi, F .
NATURE, 2001, 413 (6858) :814-821
[19]   Short peptides conferring resistance to macrolide antibiotics [J].
Tenson, T ;
Mankin, AS .
PEPTIDES, 2001, 22 (10) :1661-1668
[20]   Detecting and measuring cotranslational protein degradation in vivo [J].
Turner, GC ;
Varshavsky, A .
SCIENCE, 2000, 289 (5487) :2117-2120