Comparative evolutionary genomics of human malaria parasites

被引:47
作者
Carlton, Jane M. [1 ]
Escalante, Ananias A. [2 ]
Neafsey, Daniel [3 ,4 ]
Volkman, Sarah K. [5 ,6 ]
机构
[1] NYU, Langone Med Ctr, Dept Med Parasitol, New York, NY 10010 USA
[2] Arizona State Univ, Sch Life Sci, Tempe, AZ 85286 USA
[3] MIT, Broad Inst, Cambridge, MA 02142 USA
[4] Harvard Univ, Cambridge, MA 02142 USA
[5] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
[6] Simmons Coll, Sch Hlth Studies, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/j.pt.2008.09.003
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
The parasites Plasmodium falciparum and Plasmodium vivax are responsible for the majority of human malaria cases worldwide. Despite many similarities in their biology, they frequently are studied in isolation. With the completion of the P. vivax genome and the generation of an initial P. falciparum genetic diversity map, attempts are being made to infer inter- and intra-species genome evolution. Here, we briefly review our current knowledge of comparative evolutionary genomics of the two species in the light of several presentations at the Molecular Approaches to Malaria 2008 meeting in Lorne, Australia and ask the question: can evolutionary genomics of one species inform the other?
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收藏
页码:545 / 550
页数:6
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