Macrophage plasticity and polarization in tissue repair and remodelling

被引：2142

作者：

Mantovani, Alberto ^{[1
,2
]}

Biswas, Subhra K. ^{[3
]}

Galdiero, Maria Rosaria ^{[2
,4
]}

Sica, Antonio ^{[2
,5
]}

Locati, Massimo ^{[2
]}

机构：

[1] Univ Milan, Ist Clin Humanitas, Dept Biotechnol & Translat Med, I-20089 Milan, Italy

[2] Humanitas Clin & Res Ctr, I-20089 Milan, Italy

[3] ASTAR, Singapore Immunol Network SIgN, Singapore, Singapore

[4] Univ Naples Federico II, Div Clin Immunol & Allergy, Naples, Italy

[5] Univ Piemonte Orientale Amedeo Avogadro, Dept Pharmaceut Sci, Novara, Italy

来源：

JOURNAL OF PATHOLOGY | 2013年 / 229卷 / 02期

关键词：

macrophage; activation; polarization; resolution; healing; tissue repair; tissue remodelling; ALTERNATIVELY ACTIVATED MACROPHAGES; TUMOR-ASSOCIATED MACROPHAGES; MESENCHYMAL STEM-CELLS; MYELOID CELLS; NERVOUS-SYSTEM; IL-33; SHIFTS; T-CELLS; CANCER; MONOCYTES; INFLAMMATION;

D O I：

10.1002/path.4133

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Mononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M2 or an M2-like activation mode. Macrophages are credited with an essential role in remodelling during ontogenesis. In extraembryonic life, under homeostatic conditions, the macrophage trophic and remodelling functions are recapitulated in tissues such as bone, mammary gland, decidua and placenta. In pathology, macrophages are key components of tissue repair and remodelling that occur during wound healing, allergy, parasite infection and cancer. Interaction with cells bearing stem or progenitor cell properties is likely an important component of the role of macrophages in repair and remodelling. These properties of cells of the monocytemacrophage lineage may represent a tool and a target for therapeutic exploitation.

引用

页码：176 / 185

页数：10

共 144 条

[1]

Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes [J].