Columnar self-assembled ureido crown ethers: An example of ion-channel organization in lipid bilayers

被引:140
作者
Cazacu, Adinela
Tong, Christine
van der Lee, Arie
Fyles, Thomas M. [1 ]
Barboiu, Mihail
机构
[1] Univ Victoria, Dept Chem, Victoria, BC V8W 3V6, Canada
[2] CNRS, UMR 5635, Inst Europeen Membranes, F-34095 Montpellier 5, France
关键词
D O I
10.1021/ja061861w
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The self-assembly of ureido crown-ether derivatives has been examined in homogeneous solution, in the solid state, and in planar bilayer membranes. The self-assembly is driven by head-to-tail hydrogen bonding between the urea functional groups. Dimers and higher oligomers are formed in CDCl3 solution as assessed by the change in the ureido NH chemical shift as a function of concentration. Single-crystal X-ray diffraction shows that an antiparallel association of the ureas produces columnar channels composed of face-to-face crown ethers. Powder X-ray diffraction studies also show the presence of a minor phase based upon a parallel urea association leading to an alternative columnar arrangement of the crown ethers. In bilayer membranes at low concentration of ureido crown ether added, membrane disruption is observed together with rare single-channel openings, but at higher concentration, a rich array of interconverting channel conductance states is observed. The channel results are interpreted as arising from discreet stacks of ureido crown ethers where the transport of cations would occur via the macrocycles, admixed with larger pores formed by association of the crown ether headgroups around a central large pore.
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收藏
页码:9541 / 9548
页数:8
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