CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling

被引：205

作者：

Price, MA ^{[1
]}

机构：

[1] Univ Sheffield, Ctr Dev & Biomed Genet, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England

来源：

GENES & DEVELOPMENT | 2006年 / 20卷 / 04期

关键词：

casein kinase I; Wnt signaling; Hedgehog signaling;

D O I：

10.1101/gad.1394306

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Multiple members of the casein kinase I family of serine/threonine protein kinases are involved in positive and negative roles in Wnt and Hedgehog signaling. Here I review these roles, including recent results on casein kinase I (CKI) phosphorylation and activation of LRP6, and CKI phosphorylation of Ci and mediation of Ci-Slimb/beta-TrCP binding.

引用

页码：399 / 410

页数：12

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