Nature of driving force for protein folding: A result from analyzing the statistical potential

被引:180
作者
Li, H
Tang, C
Wingreen, NS
机构
[1] NEC Research Institute, Princeton, NJ, 08540
关键词
D O I
10.1103/PhysRevLett.79.765
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
In a statistical approach to protein structure analysis, Miyazawa and Jernigan derived a 20 X 20 matrix of inter-residue contact energies between different types of amino acids. Using the method of eigenvalue decomposition, we find that the Miyazawa-Jernigan matrix can be accurately reconstructed from its first two principal component vectors as M-ij = C-0 + C-1(q(i)) + q(i)) + C(2)q(i)q(i), with constant C's, and 20 q values associated with the 20 amino acids. This regularity is due to hydrophobic interactions and a force of demixing, the latter obeying Hildebrand's solubility theory of simple liquids.
引用
收藏
页码:765 / 768
页数:4
相关论文
共 26 条
[21]   CONFIGURATIONAL STATISTICS OF A DISORDERED POLYMER-CHAIN [J].
OBUKHOV, SP .
JOURNAL OF PHYSICS A-MATHEMATICAL AND GENERAL, 1986, 19 (17) :3655-3664
[22]   FREEZING TRANSITION OF RANDOM HETEROPOLYMERS CONSISTING OF AN ARBITRARY SET OF MONOMERS [J].
PANDE, VS ;
GROSBERG, AY ;
TANAKA, T .
PHYSICAL REVIEW E, 1995, 51 (04) :3381-3392
[24]   USE OF HELICAL WHEELS TO REPRESENT STRUCTURES OF PROTEINS AND TO IDENTIFY SEGMENTS WITH HELICAL POTENTIAL [J].
SCHIFFER, M ;
EDMUNDSO.AB .
BIOPHYSICAL JOURNAL, 1967, 7 (02) :121-&
[25]   PROTEINS WITH SELECTED SEQUENCES FOLD INTO UNIQUE NATIVE CONFORMATION [J].
SHAKHNOVICH, EI .
PHYSICAL REVIEW LETTERS, 1994, 72 (24) :3907-3910
[26]   Statistical potentials extracted from protein structures: How accurate are they? [J].
Thomas, PD ;
Dill, KA .
JOURNAL OF MOLECULAR BIOLOGY, 1996, 257 (02) :457-469