The inhibitory effect of norepinephrine on the migration of ES-2 ovarian carcinoma cells involves a Rap1-dependent pathway

被引：29

作者：

Bastian, Philipp ^{[1
]}

Balcarek, Agnieszka ^{[1
]}

Altanis, Christina ^{[1
]}

Strell, Carina ^{[1
]}

Niggemann, Bernd ^{[1
]}

Zaenker, Kurt S. ^{[1
]}

Entschladen, Frank ^{[1
]}

机构：

[1] Univ Witten Herdecke, Inst Immunol, D-58448 Witten, Germany

来源：

CANCER LETTERS | 2009年 / 274卷 / 02期

关键词：

Carcinoma cells; Metastasis formation; Signal transduction; cAMP; PHOSPHOLIPASE-C-EPSILON; E-CADHERIN EXPRESSION; BETA-BLOCKERS; BREAST-CANCER; ADHESION; RAP1; CHEMOTAXIS; RECEPTOR; RISK; EPAC;

D O I：

10.1016/j.canlet.2008.09.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Our previous studies have shown that norepinephrine induces the migratory activity of human PC-3 prostate, SW 480 colon and MDA-MB-468 breast carcinoma cells. In contrast to these results, we show here that human ES-2 ovarian carcinoma cells have a reduced migratory activity after norepinephrine treatment. This inhibitory effect is possibly mediated by a cAMP-dependent activation of the small GTPase Rap1 via Epac. Furthermore, a key signalling event of the promigratory effect of norepinephrine in the above mentioned carcinoma cells is the activation of phospholipase C enzymes. In ES-2 cells, this part of the signalling cascade is constitutively active. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：218 / 224

页数：7

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