Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia

被引：28

作者：

Assiri, Abdullah M. ^{[1
]}

Midgley, Claire M. ^{[4
,5
]}

Abedi, Glen R. ^{[4
]}

Bin Saeed, Abdulaziz ^{[1
,2
]}

Almasri, Malak M. ^{[1
]}

Lu, Xiaoyan ^{[4
]}

Al-Abdely, Hail M. ^{[1
]}

Abdalla, Osman ^{[1
]}

Mohammed, Mutaz ^{[1
]}

Algarni, Homoud S. ^{[1
]}

Alhakeem, Raafat F. ^{[1
]}

Sakthivel, Senthilkumar K. ^{[4
]}

Nooh, Randa ^{[1
,3
]}

Alshayab, Zainab ^{[1
,3
]}

Alessa, Mohammad ^{[1
,3
]}

Srinivasamoorthy, Ganesh ^{[4
]}

AlQahtani, Saeed Yahya ^{[1
]}

Kheyami, Ali ^{[1
]}

HajOmar, Waleed Husein ^{[1
]}

Banaser, Talib M. ^{[1
]}

Esmaeel, Ahmad ^{[1
]}

Hall, Aron J. ^{[4
]}

Curns, Aaron T. ^{[4
]}

Tamin, Azaibi ^{[4
]}

Alsharef, Ali Abraheem ^{[1
]}

Erdman, Dean ^{[4
]}

Watson, John T. ^{[4
]}

Gerber, Susan I. ^{[4
]}

机构：

[1] King Saud Med City, Minist Hlth, Riyadh, Saudi Arabia

[2] King Saud Med City, Dept Family & Community Med, Riyadh, Saudi Arabia

[3] Minist Hlth, Field Epidemiol Training Program, Riyadh, Saudi Arabia

[4] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA

[5] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2016年 / 214卷 / 05期

关键词：

Middle East respiratory syndrome; MERS; coronavirus; MERS epidemiology; MERS transmission; MERS phylogeny; recombinant; Saudi Arabia; DROMEDARY CAMELS; MERS-COV; FAMILY CLUSTER; EMERGENCE; INFECTION; OUTBREAK; TRANSMISSION; EVOLUTION; GENOTYPE; OMAN;

D O I：

10.1093/infdis/jiw236

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans. Fundamental questions about circulating viruses and transmission routes remain. Methods.aEuro integral We assessed routinely collected epidemiologic data for MERS-CoV cases reported in Saudi Arabia during 1 January-30 June 2015 and conducted a more detailed investigation of cases reported during February 2015. Available respiratory specimens were obtained for sequencing. Results.aEuro integral During the study period, 216 MERS-CoV cases were reported. Full genome (n = 17) or spike gene sequences (n = 82) were obtained from 99 individuals. Most sequences (72 of 99 [73%]) formed a discrete, novel recombinant subclade (NRC-2015), which was detected in 6 regions and became predominant by June 2015. No clinical differences were noted between clades. Among 87 cases reported during February 2015, 13 had no recognized risks for secondary acquisition; 12 of these 13 also denied camel contact. Most viruses (8 of 9) from these 13 individuals belonged to NRC-2015. Discussions.aEuro integral Our findings document the spread and eventual predominance of NRC-2015 in humans in Saudi Arabia during the first half of 2015. Our identification of cases without recognized risk factors but with similar virus sequences indicates the need for better understanding of risk factors for MERS-CoV transmission.

引用

页码：712 / 721

页数：10

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