Ru(II) Complexes of N-Alkylated TsDPEN Ligands in Asymmetric Transfer Hydrogenation of Ketones and Imines

被引：141

作者：

Martins, Jose E. D. ^{[1
]}

Clarkson, Guy J. ^{[1
]}

Wills, Martin ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

HYDROXYCYCLOPENTADIENYL RUTHENIUM HYDRIDE; ALCOHOL)-CATALYZED TRANSFER HYDROGENATION; FORMIC-ACID; BIFUNCTIONAL CATALYSIS; EXPERIMENTAL SUPPORT; PRACTICAL SYNTHESIS; AROMATIC KETONES; RHODIUM; MECHANISM; ALCOHOLS;

D O I：

10.1021/ol802801p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Alkylated TsDPEN derivatives bearing a small alkyl group act as highly efficient ligands in Ru(II) complexes for the asymmetric transfer hydrogenation of imines and ketones. A larger alkyl group serves to significantly reduce the activity of the catalyst; however, high enantiomeric excesses are still obtained. An X-ray crystal structure of the N-benzyl derivative reveals a conformation that permits hydrogen transfer through a six-membered transition state. A transition state structure for the imine reduction process is proposed.

引用

页码：847 / 850

页数：4

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