An investigation into the tether length and substitution pattern of arene-substituted complexes for asymmetric transfer hydrogenation of ketones

被引：115

作者：

Cheung, Fung K. ^{[1
]}

Lin, Changxue

Minissi, Franco

Criville, Adriana Lorente

Graham, Mark A.

Fox, David J.

Wills, Martin

机构：

[1] Univ Warwick, Dept Chem, Asymmet Catalysis Grp, Coventry CV4 7AL, W Midlands, England

[2] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 22期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/ol702226j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of Ru(II) catalysts were prepared and tested in the asymmetric transfer hydrogenation of ketones. The catalyst containing a "4-carbon" tether gave the fastest rates of ketone reduction. This is due to both increased rate of regeneration of hydride "Ru-H" and increased rate of ketone reduction. Several classes of ketone were reduced in enantiomeric excesses of up to 97%. Substituents on the arene ring of the catalyst influence the reaction rate and enantioselectivity.

引用

页码：4659 / 4662

页数：4

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