Asymmetric transfer hydrogenation of α-aminoalkyl α′-chloromethyl ketones with chiral Rh complexes

被引：81

作者：

Hamada, T

Torii, T

Onishi, T

Izawa, K

Ikariya, T

机构：

[1] Ajinomoto Co Inc, Aminosci Lab, Kawasaki Ku, Kawasaki, Kanagawa 2108681, Japan

[2] Tokyo Inst Technol, Grad Sch Sci & Engn, Meguro Ku, Tokyo 1528552, Japan

[3] Tokyo Inst Technol, Frontier Collaborat Res Ctr, Meguro Ku, Tokyo 1528552, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 21期

关键词：

D O I：

10.1021/jo0491455

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric transfer hydrogenation of N-substituted (3S)-3-amino-1-chloro-4-phenyl-2-butanones in the presence of Cp*RhCl[(R,R)-Tsdpen] (SIC = 1000) with a mixture of formic acid/triethylamine gave N-substituted (2R,3S)-3-amino-1-chloro-2-hydroxy-4-phenylbutanes with up to 93% de in a quantitative yield, and reduction with the enantiomeric catalyst Cp*RhCl[(S,S)-Tsdpen] gave (2S,3S)diastereomeric alcohol with up to 96% de.

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页码：7391 / 7394

页数：4

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