Connecting Genomic Alterations to Cancer Biology with Proteomics: The NCI Clinical Proteomic Tumor Analysis Consortium

被引：252

作者：

Ellis, Matthew J. ^{[1
]}

Gillette, Michael ^{[3
]}

Carr, Steven A. ^{[3
]}

Paulovich, Amanda G. ^{[4
]}

Smith, Richard D. ^{[5
]}

Rodland, Karin K. ^{[5
]}

Townsend, R. Reid ^{[2
]}

Kinsinger, Christopher ^{[6
]}

Mesri, Mehdi ^{[6
]}

Rodriguez, Henry ^{[6
]}

Liebler, Daniel C. ^{[7
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, Div Oncol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Med, Div Endocrinol & Metab, St Louis, MO 63110 USA

[3] Broad Inst MIT & Harvard, Cambridge, MA USA

[4] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[5] Pacific NW Natl Lab, Div Biol Sci, Richland, WA 99352 USA

[6] NCI, Off Canc Clin Prote Res, NIH, Bethesda, MD 20892 USA

[7] Vanderbilt Ingram Canc Ctr, Jim Ayers Inst Canc Detect & Diag, Nashville, TN USA

来源：

CANCER DISCOVERY | 2013年 / 3卷 / 10期

关键词：

CELL-LINES; QUANTIFICATION; PROTEINS;

D O I：

10.1158/2159-8290.CD-13-0219

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium is applying the latest generation of proteomic technologies to genomically annotated tumors from The Cancer Genome Atlas (TCGA) program, a joint initiative of the NCI and the National Human Genome Research Institute. By providing a fully integrated accounting of DNA, RNA, and protein abnormalities in individual tumors, these datasets will illuminate the complex relationship between genomic abnormalities and cancer phenotypes, thus producing biologic insights as well as a wave of novel candidate biomarkers and therapeutic targets amenable to verifi cation using targeted mass spectrometry methods. (C) 2013 AACR.

引用

页码：1108 / 1112

页数：5

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