The Intestinal Crypt, A Prototype Stem Cell Compartment

被引：900

作者：

Clevers, Hans ^{[1
,2
]}

机构：

[1] Royal Netherlands Acad Arts & Sci, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands

[2] Univ Med Ctr, NL-3584 CX Utrecht, Netherlands

来源：

CELL | 2013年 / 154卷 / 02期

关键词：

MOUSE SMALL INTESTINE; WNT/BETA-CATENIN; BETA-CATENIN; PANETH CELLS; PROGENITOR CELLS; SECRETORY PROGENITOR; JUVENILE POLYPOSIS; COLORECTAL-CANCER; SELF-RENEWAL; IN-VITRO;

D O I：

10.1016/j.cell.2013.07.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal epithelium has become a prime model for studying adult stem cells in health and disease. Transgenic mouse models allow in vivo visualization and genetic lineage tracing of individual intestinal stem cells and their offspring. Fluorescently marked stem cells can be isolated for molecular analyses or can be cultured to build ever-expanding "mini-guts" in vitro. These studies are filling in the outlines of a robust homeostatic self-renewal process that defies some of the classical definitions of stem cell behavior, such as asymmetric division, quiescence, and exhaustion. © 2013 Elsevier Inc.

引用

页码：274 / 284

页数：11

共 122 条

[1] A genetic study of the role of the Wnt/β-catenin signalling in Paneth cell differentiation [J].

Andreu, Pauline ;

Peignon, Gregory ;

Slomianny, Christian ;

Taketo, Makoto M. ;

Colnot, Sabine ;

Robine, Sylvie ;

Lamarque, Dominique ;

Laurent-Puig, Pierre ;

Perret, Christine ;

Romagnolo, Beatrice .

DEVELOPMENTAL BIOLOGY, 2008, 324 (02) :288-296

[2]

[Anonymous], 1745, THESIS

[3] Identification of stem cells in small intestine and colon by marker gene Lgr5 [J].

Barker, Nick ;

van Es, Johan H. ;

Kuipers, Jeroen ;

Kujala, Pekka ;

van den Born, Maaike ;

Cozijnsen, Miranda ;

Haegebarth, Andrea ;

Korving, Jeroen ;

Begthel, Harry ;

Peters, Peter J. ;

Clevers, Hans .

NATURE, 2007, 449 (7165) :1003-U1

[4] Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls [J].

Barker, Nick ;

van Oudenaarden, Alexander ;

Clevers, Hans .

CELL STEM CELL, 2012, 11 (04) :452-460

[5] Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium [J].

Bastide, Pauline ;

Darido, Charbel ;

Pannequiri, Julie ;

Kist, Ralf ;

Robine, Sylvie ;

Marty-Double, Christiane ;

Bibeau, Frederic ;

Scherer, Gerd ;

Joubert, Dominique ;

Hollande, Frederic ;

Blache, Philippe ;

Jay, Philippe .

JOURNAL OF CELL BIOLOGY, 2007, 178 (04) :635-648

[6] β-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/EphrinB [J].

Batlle, E ;

Henderson, JT ;

Beghtel, H ;

van den Born, MMW ;

Sancho, E ;

Huls, G ;

Meeldijk, J ;

Robertson, J ;

van de Wetering, M ;

Pawson, T ;

Clevers, H .

CELL, 2002, 111 (02) :251-263

[7] THE STEM-CELL ZONE OF THE SMALL INTESTINAL EPITHELIUM .1. EVIDENCE FROM PANETH CELLS IN THE ADULT-MOUSE [J].

BJERKNES, M ;

CHENG, H .

AMERICAN JOURNAL OF ANATOMY, 1981, 160 (01) :51-63

[8] THE STEM-CELL ZONE OF THE SMALL INTESTINAL EPITHELIUM .3. EVIDENCE FROM COLUMNAR, ENTEROENDOCRINE, AND MUCOUS CELLS IN THE ADULT-MOUSE [J].

BJERKNES, M ;

CHENG, H .

AMERICAN JOURNAL OF ANATOMY, 1981, 160 (01) :77-91

[9] Clonal analysis of mouse intestinal epithelial progenitors [J].

Bjerknes, M ;

Cheng, H .

GASTROENTEROLOGY, 1999, 116 (01) :7-14

[10] Origin of the brush cell lineage in the mouse intestinal epithelium [J].

Bjerknes, Matthew ;

Khandanpour, Cyrus ;

Moeroey, Tarik ;

Fujiyama, Tomoyuki ;

Hoshino, Mikio ;

Klisch, Tiemo J. ;

Ding, Qian ;

Gan, Lin ;

Wang, Jiafang ;

Martin, Martin G. ;

Cheng, Hazel .

DEVELOPMENTAL BIOLOGY, 2012, 362 (02) :194-218

← 1 2 3 4 5 6 7 8 9 10 →