The Intestinal Crypt, A Prototype Stem Cell Compartment

被引：900

作者：

Clevers, Hans ^{[1
,2
]}

机构：

[1] Royal Netherlands Acad Arts & Sci, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands

[2] Univ Med Ctr, NL-3584 CX Utrecht, Netherlands

来源：

CELL | 2013年 / 154卷 / 02期

关键词：

MOUSE SMALL INTESTINE; WNT/BETA-CATENIN; BETA-CATENIN; PANETH CELLS; PROGENITOR CELLS; SECRETORY PROGENITOR; JUVENILE POLYPOSIS; COLORECTAL-CANCER; SELF-RENEWAL; IN-VITRO;

D O I：

10.1016/j.cell.2013.07.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal epithelium has become a prime model for studying adult stem cells in health and disease. Transgenic mouse models allow in vivo visualization and genetic lineage tracing of individual intestinal stem cells and their offspring. Fluorescently marked stem cells can be isolated for molecular analyses or can be cultured to build ever-expanding "mini-guts" in vitro. These studies are filling in the outlines of a robust homeostatic self-renewal process that defies some of the classical definitions of stem cell behavior, such as asymmetric division, quiescence, and exhaustion. © 2013 Elsevier Inc.

引用

页码：274 / 284

页数：11

共 122 条

[21] Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling [J].

de Lau, Wim ;

Barker, Nick ;

Low, Teck Y. ;

Koo, Bon-Kyoung ;

Li, Vivian S. W. ;

Teunissen, Hans ;

Kujala, Pekka ;

Haegebarth, Andrea ;

Peters, Peter J. ;

van de Wetering, Marc ;

Stange, Daniel E. ;

van Es, Johan E. ;

Guardavaccaro, Daniele ;

Schasfoort, Richard B. M. ;

Mohri, Yasuaki ;

Nishimori, Katsuhiko ;

Mohammed, Shabaz ;

Heck, Albert J. R. ;

Clevers, Hans .

NATURE, 2011, 476 (7360) :293-U57

[22] Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1) [J].

Durand, Aurelie ;

Donahue, Bridgitte ;

Peignon, Gregory ;

Letourneur, Franck ;

Cagnard, Nicolas ;

Slomianny, Christian ;

Perret, Christine ;

Shroyer, Noah F. ;

Romagnolo, Beatrice .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (23) :8965-8970

[23] Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregation [J].

Escobar, Marion ;

Nicolas, Pierre ;

Sangar, Fatiha ;

Laurent-Chabalier, Sabine ;

Clair, Philippe ;

Joubert, Dominique ;

Jay, Philippe ;

Legraverend, Catherine .

NATURE COMMUNICATIONS, 2011, 2

[24] Gut-trophic effects of keratinocyte growth factor in rat small intestine and colon during enteral refeeding [J].

Estivariz, CF ;

Jonas, CR ;

Gu, LH ;

Diaz, EE ;

Wallace, TM ;

Pascal, RR ;

Farrell, CL ;

Ziegler, TR .

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 1998, 22 (05) :259-267

[25] Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells [J].

Farin, Henner F. ;

Van Es, Johan H. ;

Clevers, Hans .

GASTROENTEROLOGY, 2012, 143 (06) :1518-+

[26] Wnt/β-Catenin is essential for intestinal Homeostasis and maintenance of intestinal stem cells [J].

Fevr, Tea ;

Robine, Sylvie ;

Louvard, Daniel ;

Huelsken, Joerg .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (21) :7551-7559

[27] Notch signals control the fate of immature progenitor cells in the intestine [J].

Fre, S ;

Huyghe, M ;

Mourikis, P ;

Robine, S ;

Louvard, D ;

Artavanis-Tsakonas, S .

NATURE, 2005, 435 (7044) :964-968

[28] CELLULAR DYNAMICS IN THE INTESTINAL MUCOSA - THE EFFECT OF IRRADIATION ON EPITHELIAL MATURATION AND MIGRATION [J].

FRIEDMAN, NB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1945, 81 (06) :553-&

[29] Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice [J].

Garabedian, EM ;

Roberts, LJJ ;

McNevin, MS ;

Gordon, JI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (38) :23729-23740

[30] A Mouse Model of Acrodermatitis Enteropathica: Loss of Intestine Zinc Transporter ZIP4 (Slc39a4) Disrupts the Stem Cell Niche and Intestine Integrity [J].

Geiser, Jim ;

Venken, Koen J. T. ;

De Lisle, Robert C. ;

Andrews, Glen K. .

PLOS GENETICS, 2012, 8 (06)

← 1 2 3 4 5 6 7 8 9 10 →