The Intestinal Crypt, A Prototype Stem Cell Compartment

被引：900

作者：

Clevers, Hans ^{[1
,2
]}

机构：

[1] Royal Netherlands Acad Arts & Sci, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands

[2] Univ Med Ctr, NL-3584 CX Utrecht, Netherlands

来源：

CELL | 2013年 / 154卷 / 02期

关键词：

MOUSE SMALL INTESTINE; WNT/BETA-CATENIN; BETA-CATENIN; PANETH CELLS; PROGENITOR CELLS; SECRETORY PROGENITOR; JUVENILE POLYPOSIS; COLORECTAL-CANCER; SELF-RENEWAL; IN-VITRO;

D O I：

10.1016/j.cell.2013.07.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal epithelium has become a prime model for studying adult stem cells in health and disease. Transgenic mouse models allow in vivo visualization and genetic lineage tracing of individual intestinal stem cells and their offspring. Fluorescently marked stem cells can be isolated for molecular analyses or can be cultured to build ever-expanding "mini-guts" in vitro. These studies are filling in the outlines of a robust homeostatic self-renewal process that defies some of the classical definitions of stem cell behavior, such as asymmetric division, quiescence, and exhaustion. © 2013 Elsevier Inc.

引用

页码：274 / 284

页数：11

共 122 条

[81] Paneth Cells in Intestinal Homeostasis and Tissue Injury [J].

Roth, Sabrina ;

Franken, Patrick ;

Sacchetti, Andrea ;

Kremer, Andreas ;

Anderson, Kurt ;

Sansom, Owen ;

Fodde, Riccardo .

PLOS ONE, 2012, 7 (06)

[82] ASSOCIATION OF THE APC GENE-PRODUCT WITH BETA-CATENIN [J].

RUBINFELD, B ;

SOUZA, B ;

ALBERT, I ;

MULLER, O ;

CHAMBERLAIN, SH ;

MASIARZ, FR ;

MUNEMITSU, S ;

POLAKIS, P .

SCIENCE, 1993, 262 (5140) :1731-1734

[83] Bmi1 is expressed in vivo in intestinal stem cells [J].

Sangiorgi, Eugenio ;

Capecchi, Mario R. .

NATURE GENETICS, 2008, 40 (07) :915-920

[84] Myc deletion rescues Apc deficiency in the small intestine [J].

Sansom, Owen J. ;

Meniel, Valerie S. ;

Muncan, Vanesa ;

Phesse, Toby J. ;

Wilkins, Julie A. ;

Reed, Karen R. ;

Vass, J. Keith ;

Athineos, Dimitris ;

Clevers, Hans ;

Clarke, Alan R. .

NATURE, 2007, 446 (7136) :676-679

[85] Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts [J].

Sato, Toshiro ;

van Es, Johan H. ;

Snippert, Hugo J. ;

Stange, Daniel E. ;

Vries, Robert G. ;

van den Born, Maaike ;

Barker, Nick ;

Shroyer, Noah F. ;

van de Wetering, Marc ;

Clevers, Hans .

NATURE, 2011, 469 (7330) :415-+

[86] Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche [J].

Sato, Toshiro ;

Vries, Robert G. ;

Snippert, Hugo J. ;

van de Wetering, Marc ;

Barker, Nick ;

Stange, Daniel E. ;

van Es, Johan H. ;

Abo, Arie ;

Kujala, Pekka ;

Peters, Peter J. ;

Clevers, Hans .

NATURE, 2009, 459 (7244) :262-U147

[87] Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes [J].

Schepers, Arnout G. ;

Vries, Robert ;

van den Born, Maaike ;

van de Wetering, Marc ;

Clevers, Hans .

EMBO JOURNAL, 2011, 30 (06) :1104-1109

[88] Recurrent R-spondin fusions in colon cancer [J].

Seshagiri, Somasekar ;

Stawiski, Eric W. ;

Durinck, Steffen ;

Modrusan, Zora ;

Storm, Elaine E. ;

Conboy, Caitlin B. ;

Chaudhuri, Subhra ;

Guan, Yinghui ;

Janakiraman, Vasantharajan ;

Jaiswal, Bijay S. ;

Guillory, Joseph ;

Ha, Connie ;

Dijkgraaf, Gerrit J. P. ;

Stinson, Jeremy ;

Gnad, Florian ;

Huntley, Melanie A. ;

Degenhardt, Jeremiah D. ;

Haverty, Peter M. ;

Bourgon, Richard ;

Wang, Weiru ;

Koeppen, Hartmut ;

Gentleman, Robert ;

Starr, Timothy K. ;

Zhang, Zemin ;

Largaespada, David A. ;

Wu, Thomas D. ;

de Sauvage, Frederic J. .

NATURE, 2012, 488 (7413) :660-+

[89] Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation [J].

Shroyer, NF ;

Wallis, D ;

Venken, KJT ;

Bellen, HJ ;

Zoghbi, HY .

GENES & DEVELOPMENT, 2005, 19 (20) :2412-2417

[90] Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis [J].

Shroyer, Noah F. ;

Helmrath, Michael A. ;

Wang, Vincent Y. -C. ;

Antalffy, Barbara ;

Henning, Susan J. ;

Zoghbi, Huda Y. .

GASTROENTEROLOGY, 2007, 132 (07) :2478-2488

← 4 5 6 7 8 9 10 11 12 13 →