Potentiometric enantioselective membrane electrode for s-enalapril assay

被引：19

作者：

Aboul-Enein, HY

Stefan, RI

van Staden, JF

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Bioanalyt & Drug Dev Lab, Biol & Med Res Dept MBC03, Riyadh 11211, Saudi Arabia

[2] Univ Pretoria, Dept Chem, ZA-0002 Pretoria, South Africa

来源：

ANALUSIS | 1999年 / 27卷 / 01期

关键词：

potentiometry; enantioselective membrane electrode; enantioselective analysis; 2-hydroxy-3-trimethylammoniopropyl-beta-cyclodextrin; S-enalapril;

D O I：

10.1051/analusis:1999105

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel potentiometric, enantioselective membrane electrode based on graphite paste (graphite powder and paraffin oil), impregnated with 10(-3) mol/L 2-hydroxy-3-trimethylammoniopropyl-beta-cyclodextrin (as chloride salt) solution, has been constructed. The potentiometric, enantioselective membrane electrode can be used for the reliable assay of S-enalapril as raw material and from its pharmaceutical formulations in the concentration range of 3.6 x 10(-5) - 6.4 x 10(-2) mol/L, with a detection limit of 1.0 x 10(-5) mol/L and with an average recovery of 99.96% (RSD = 0.098%), using a chronopotentiometric (zero current) technique. The enantioselectivity was determined versus D-proline and it was shown that only L-proline is the main interfering compound. The surface of the electrode can be regenerated by simply polishing to obtain a fresh surface which is ready to be used in a new assay.

引用

页码：53 / 56

页数：4

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