OPTICAL RESOLUTION MECHANISMS OF UNICONAZOLE AND STRUCTURALLY RELATED-COMPOUNDS ON CYCLODEXTRIN-BONDED COLUMNS

被引：16

作者：

FURUTA, R ^{[1
]}

NAKAZAWA, H ^{[1
]}

机构：

[1] SUMITOMO CHEM CO LTD,TAKARAZUKA RES CTR,TAKARAZUKA,HYOGO 665,JAPAN

来源：

CHROMATOGRAPHIA | 1993年 / 35卷 / 9-12期

关键词：

COLUMN LIQUID CHROMATOGRAPHY; CYCLODEXTRIN-BONDED PHASE; OPTICAL RESOLUTION; UNICONAZOLE INCLUSION COMPLEX; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

D O I：

10.1007/BF02267916

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Enantiomers of uniconazole have been separated by high-performance liquid chromatography on a gamma-cyclodextrin-bonded column and the mechanisms of the chiral recognition have been studied. From investigations on the retention and resolution of structurally related compounds of uniconazole on gamma-and beta-cyclodextrin columns the benzene ring and alkyl group of the solute were found to play an important role in the formation of the CD complex and in the chiral recognition. Nuclear magnetic resonance data for the model systems of uniconazole and some analogs also supported these conclusions.

引用

页码：555 / 559

页数：5

共 15 条

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