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Pathways of apoptosis in lymphocyte development, homeostasis, and disease

被引：312
作者：
Rathmell, JC
Thompson, CB [1 ]
机构：
[1] Univ Penn, Abramson Family Canc Res Inst, Dept Canc Biol, Philadelphia, PA 19104 USA
[2] Univ Penn, Abramson Family Canc Res Inst, Dept Med, Philadelphia, PA 19104 USA
来源：
CELL | 2002年 / 109卷
关键词：
D O I：
10.1016/S0092-8674(02)00704-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Apoptosis plays a critical role in lymphocyte development and homeostasis. Enhanced lymphocyte apoptosis can cause immunodeficiency through cell loss. Conversely, inhibition of apoptosis can lead to the development of autoimmunity or lymphoma. Two major pathways contribute to the regulation of lymphocyte cell death, death-by-neglect and death-by-instruction.
引用
收藏
页码：S97 / S107
页数：11
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