学术探索
学术期刊
新闻热点
数据分析
智能评审

Gene therapy for cardiovascular disorders - Is there a future?

被引：9
作者：
Metcalfe, BL
Sellers, KW
Jeng, MJR
Huentelman, MJ
Katovich, MJ
Raizada, MK
机构：
[1] Univ Florida, Coll Med, Dept Physiol & Funct Genom, Gainesville, FL 32610 USA
[2] Univ Florida, Coll Pharm, Evelyn F & William Mcknight Brain Inst, Dept Pharmacodynam, Gainesville, FL 32610 USA
来源：
NEW VISTAS IN THERAPEUTICS, FROM DRUG DESIGN TO GENE THERAPY: DRUG-RESISTANT TUBERCULOSIS, FROM MOLECULES TO MACRO-ECONOMICS | 2001年 / 953卷
关键词：
gene therapy; cardiovascular disorders; viral vectors; restenosis; thrombosis; hypertension; ischemia; heart failure;
D O I：
10.1111/j.1749-6632.2001.tb11358.x
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Incidence of cardiovascular disease has reached epidemic proportions in spite of recent advances in improving the efficacy of pharmacotherapeutics. This has led many to conclude that drug therapy has reached a plateau in its effectiveness. As a result, our efforts have been diverted to explore the use of gene transfer approaches for long-term control of these pathophysiological conditions. The purpose of this review is to present various approaches that are being undertaken to provide "proof of principle" for gene therapy for cardiovascular diseases. Finally, we will discuss the future of gene therapy and other new technologies that may further advance this field of therapeutics.
引用
收藏
页码：31 / 42
页数：12
相关论文
共 55 条
[1]  
*AM HEART ASS, 2001, HEART STROK STAT UPD
[2]  
Buchschacher GL, 2000, BLOOD, V95, P2499
[3]   CYTOSTATIC GENE-THERAPY FOR VASCULAR PROLIFERATIVE DISORDERS WITH A CONSTITUTIVELY ACTIVE FORM OF THE RETINOBLASTOMA GENE-PRODUCT [J].
CHANG, MW ;
BARR, E ;
SELTZER, J ;
JIANG, YQ ;
NABEL, GJ ;
NABEL, EG ;
PARMACEK, MS ;
LEIDEN, JM .
SCIENCE, 1995, 267 (5197) :518-522
[4]   Production of first generation adenovirus vectors: a review [J].
Danthinne, X ;
Imperiale, MJ .
GENE THERAPY, 2000, 7 (20) :1707-1714
[5]   Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca2+-ATPase in a rat model of heart failure [J].
del Monte, F ;
Williams, E ;
Lebeche, D ;
Schmidt, U ;
Rosenzweig, A ;
Gwathmey, JK ;
Lewandowski, ED ;
Hajjar, RJ .
CIRCULATION, 2001, 104 (12) :1424-1429
[6]   Adenovirus-mediated kallikrein gene delivery attenuates hypertension and protects against renal injury in deoxycorticosterone-salt rats [J].
Dobrzynski, E ;
Yoshida, H ;
Chao, J ;
Chao, L .
IMMUNOPHARMACOLOGY, 1999, 44 (1-2) :57-65
[7]   Adrenomedullin gene delivery attenuates hypertension, cardiac remodeling, and renal injury in deoxycorticosterone acetate-salt hypertensive rats [J].
Dobrzynski, E ;
Wang, C ;
Chao, J ;
Chao, L .
HYPERTENSION, 2000, 36 (06) :995-1001
[8]   Expression of exogenous tissue factor pathway inhibitor in vivo suppresses thrombus formation in injured rabbit carotid arteries [J].
Golino, P ;
Cirillo, P ;
Calabro', P ;
Ragni, M ;
D'Andrea, D ;
Avvedimento, EV ;
Vigorito, F ;
Corcione, N ;
Loffredo, F ;
Chiariello, W .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 38 (02) :569-576
[9]   IN-VIVO SUPPRESSION OF INJURY-INDUCED VASCULAR SMOOTH-MUSCLE CELL ACCUMULATION USING ADENOVIRUS-MEDIATED TRANSFER OF THE HERPES-SIMPLEX VIRUS THYMIDINE KINASE GENE [J].
GUZMAN, RJ ;
HIRSCHOWITZ, EA ;
BRODY, SL ;
CRYSTAL, RG ;
EPSTEIN, SE ;
FINKEL, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (22) :10732-10736
[10]   Prospects for gene therapy for heart failure [J].
Hajjar, RJ ;
del Monte, F ;
Matsui, T ;
Rosenzweig, A .
CIRCULATION RESEARCH, 2000, 86 (06) :616-621
123456