Detection of a Few Metallo-Protein Molecules Using Color Centers in Nanodiamonds

被引：187

作者：

Ermakova, A. ^{[1
,2
]}

Pramanik, G. ^{[3
]}

Cai, J. -M.

Algara-Siller, G.

Kaiser, U.

Weil, T. ^{[3
]}

Tzeng, Y. -K.

Chang, H. C.

McGuinness, L. P. ^{[1
,2
]}

Plenio, M. B.

Naydenov, B. ^{[1
,2
]}

Jelezko, F. ^{[1
,2
]}

机构：

[1] Univ Ulm, Inst Quantenopt, D-89069 Ulm, Germany

[2] Univ Ulm, IQST, D-89069 Ulm, Germany

[3] Univ Ulm, Inst Organ Chem 3, D-89069 Ulm, Germany

来源：

NANO LETTERS | 2013年 / 13卷 / 07期

关键词：

Nanodiamonds; biomolecules; ferritin; nitrogen-vacancy centers; optically detected magnetic resonance; NUCLEAR-MAGNETIC-RESONANCE; FLUORESCENT NANODIAMONDS; FERRITIN; ADSORPTION; NANOPARTICLES; IMMUNOSENSOR; LEVEL; CELLS; SPIN;

D O I：

10.1021/nl4015233

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Nanometer-sized diamonds containing nitrogen-vacancy defect centers (NV) are promising nanosensors in biological environments due to their biocompatibility, bright fluorescence, and high magnetic sensitivity at ambient conditions. Here we report on the detection of ferritin molecules using magnetic noise induced by the inner paramagnetic iron as a contrast mechanism. We observe a significant reduction of both coherence and relaxation time due to the presence of ferritin on the surface of nanodiamonds. Our theoretical model is in excellent agreement with the experimental data and establishes this method as a novel sensing technology for proteins.

引用

页码：3305 / 3309

页数：5

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