High resolution imaging of native biological sample surfaces using scanning probe microscopy

被引：146

作者：

Engel, A ^{[1
]}

Schoenenberger, CA ^{[1
]}

Muller, DJ ^{[1
]}

机构：

[1] FORSCHUNGSZENTRUM JULICH, FORSCHUNGSZENTRUM, IBI STRUCT BIOL 2, D-52425 JULICH, GERMANY

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0959-440X(97)80037-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The possibility of acquiring high resolution topographs using scanning probe microscopes under physiological conditions allows the observation of biomolecules at work. Progress has recently been made in imaging protein-DNA complexes, individual oligomers and protein arrays. Scanning probe microscopes are now tools that complement X-ray crystallography and electron microscopy.

引用

页码：279 / 284

页数：6

共 34 条

[1] SINGLE MOLECULES OBSERVED BY NEAR-FIELD SCANNING OPTICAL MICROSCOPY [J].

BETZIG, E ;

CHICHESTER, RJ .

SCIENCE, 1993, 262 (5138) :1422-1425

[2] ATOMIC FORCE MICROSCOPE [J].

BINNIG, G ;

QUATE, CF ;

GERBER, C .

PHYSICAL REVIEW LETTERS, 1986, 56 (09) :930-933

[3]

BINNIG G, 1982, HELV PHYS ACTA, V55, P726

[4]

Bustamante C, 1996, ANNU REV BIOPH BIOM, V25, P395

[5] MEASURING SURFACE FORCES IN AQUEOUS-ELECTROLYTE SOLUTION WITH THE ATOMIC-FORCE MICROSCOPE [J].

BUTT, HJ ;

JASCHKE, M ;

DUCKER, W .

BIOELECTROCHEMISTRY AND BIOENERGETICS, 1995, 38 (01) :191-201

[6] SCAN SPEED LIMIT IN ATOMIC FORCE MICROSCOPY [J].

BUTT, HJ ;

SIEDLE, P ;

SEIFERT, K ;

FENDLER, K ;

SEEGER, T ;

BAMBERG, E ;

WEISENHORN, AL ;

GOLDIE, K ;

ENGEL, A .

JOURNAL OF MICROSCOPY-OXFORD, 1993, 169 :75-84

[7] BINDING STRENGTH BETWEEN CELL-ADHESION PROTEOGLYCANS MEASURED BY ATOMIC-FORCE MICROSCOPY [J].

DAMMER, U ;

POPESCU, O ;

WAGNER, P ;

ANSELMETTI, D ;

GUNTHERODT, HJ ;

MISEVIC, GN .

SCIENCE, 1995, 267 (5201) :1173-1175

[8] Electron-crystallographic refinement of the structure of bacteriorhodopsin [J].

Grigorieff, N ;

Ceska, TA ;

Downing, KH ;

Baldwin, JM ;

Henderson, R .

JOURNAL OF MOLECULAR BIOLOGY, 1996, 259 (03) :393-421

[9] Ligand binding: Molecular mechanics calculation of the streptavidin biotin rupture force [J].

Grubmuller, H ;

Heymann, B ;

Tavan, P .

SCIENCE, 1996, 271 (5251) :997-999

[10] SCANNING-TUNNELING-MICROSCOPY OF INSULATORS AND BIOLOGICAL SPECIMENS BASED ON LATERAL CONDUCTIVITY OF ULTRATHIN WATER FILMS [J].

GUCKENBERGER, R ;

HEIM, M ;

CEVC, G ;

KNAPP, HF ;

WIEGRABE, W ;

HILLEBRAND, A .

SCIENCE, 1994, 266 (5190) :1538-1540

← 1 2 3 4 →