Cellular and mitochondrial iron homeostasis in vertebrates

被引：90

作者：

Chen, Caiyong

Paw, Barry H. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2012年 / 1823卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Iron; Transferrin; Non-transferrin bound iron; Mitochondrion; Mitoferrin; TRANSFERRIN RECEPTOR 2; GELATINASE-ASSOCIATED LIPOCALIN; HEREDITARY HEMOCHROMATOSIS PROTEIN; BINDING CASSETTE TRANSPORTER; SULFUR CLUSTER BIOGENESIS; SINGLE CALCIUM-CHANNELS; H-FERRITIN; MICROCYTIC ANEMIA; BOUND IRON; ERYTHROPOIETIC PROTOPORPHYRIA;

D O I：

10.1016/j.bbamcr.2012.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Iron plays an essential role in cellular metabolism and biological processes. However, due to its intrinsic redox activity, free iron is a potentially toxic molecule in cellular biochemistry. Thus, organisms have developed sophisticated ways to import, sequester, and utilize iron. The transferrin cycle is a well-studied iron uptake pathway that is important for most vertebrate cells. Circulating iron can also be imported into cells by mechanisms that are independent of transferrin. Once imported into erythroid cells, iron is predominantly consumed by the mitochondria for the biosynthesis of heme and iron sulfur clusters. This review focuses on canonical transferrin-mediated and the newly discovered, non-transferrin mediated iron uptake pathways, as well as, mitochondrial iron homeostasis in higher eukaryotes. This article is part of a Special Issue entitled: Cell Biology of Metals. (C) 2012 Elsevier BM. All rights reserved.

引用

页码：1459 / 1467

页数：9

共 147 条

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