Peripheral covalent modification of inorganic and organometallic compounds through C-C bond formation reactions

The peripheral modifications have three outstanding advantages. The first one deals with its excellence in regio- and chemoselectivity provided by cross-coupling reactions that can do precise hierarchical assemblies. The next advantage is the formation of a polydentate ligand from the modification of a coordinated ligand that facilitates the subsequent formation of multinuclear complexes as the advantage can be seen within the preparation of compounds 29-32. Finally, the preparation of both the metal-biomolecule conjugates and compounds of extended carbon-rich fragments can be made possible through the mild conditions of cross-coupling and homocoupling reactions. The types of reactions that have been discussed are: Sonogashira and Cadiot-Chodkiewicz; Suzuki and Negishi; Heck; Stille, and lastly the oxidative/reductive homocoupling reactions.