Paper-based microfluidics with high resolution, cut on a glass fiber membrane for bioassays

被引:63
作者
Fang, Xueen [1 ,2 ]
Wei, Shasha [3 ]
Kong, Jilie [1 ,2 ]
机构
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[2] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200433, Peoples R China
基金
美国国家科学基金会;
关键词
LOW-COST; DEVICES; THREAD; ASSAYS; WAX;
D O I
10.1039/c3lc51246k
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
In this report, we describe a simple, low-cost, straight forward and highly reproducible fabrication method of microfluidic systems. This system was cut on a glass fiber membrane by a common cutter without using any other sophisticated equipment or organic solvents. This format represents a novel type of paper-based microfluidics with high resolution of the microchannel down to similar to 137 mu m, comparable to those made by conventional photolithography. We successfully applied this method to microfluidics to create a star micro-array format of multiplexed urine tests in this study.
引用
收藏
页码:911 / 915
页数:5
相关论文
共 21 条
[1]   Low-cost printing of poly(dimethylsiloxane) barriers to define microchannels in paper [J].
Bruzewicz, Derek A. ;
Reches, Meital ;
Whitesides, George M. .
ANALYTICAL CHEMISTRY, 2008, 80 (09) :3387-3392
[2]   Paper Microzone Plates [J].
Carrilho, Emanuel ;
Phillips, Scott T. ;
Vella, Sarah J. ;
Martinez, Andres W. ;
Whitesides, George M. .
ANALYTICAL CHEMISTRY, 2009, 81 (15) :5990-5998
[3]   Understanding Wax Printing: A Simple Micropatterning Process for Paper-Based Microfluidics [J].
Carrilho, Emanuel ;
Martinez, Andres W. ;
Whitesides, George M. .
ANALYTICAL CHEMISTRY, 2009, 81 (16) :7091-7095
[4]   A rapid and low-cost procedure for fabrication of glass microfluidic devices [J].
Chen, Qiang ;
Li, Gang ;
Jin, Qing-Hui ;
Zhao, Jian-Long ;
Ren, Qiu-Shi ;
Xu, Yuan-Sen .
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2007, 16 (05) :1193-1200
[5]   Electrogenerated Chemiluminescence Detection in Paper-Based Microfluidic Sensors [J].
Delaney, Jacqui L. ;
Hogan, Conor F. ;
Tian, Junfei ;
Shen, Wei .
ANALYTICAL CHEMISTRY, 2011, 83 (04) :1300-1306
[6]   Microfluidic Devices Constructed by a Marker Pen on a Silica Gel Plate for Multiplex Assays [J].
Fang, Xueen ;
Chen, Hui ;
Jiang, Xingyu ;
Kong, Jilie .
ANALYTICAL CHEMISTRY, 2011, 83 (09) :3596-3599
[7]   Monolithic membrane valves and diaphragm pumps for practical large-scale integration into glass microfluidic devices [J].
Grover, WH ;
Skelley, AM ;
Liu, CN ;
Lagally, ET ;
Mathies, RA .
SENSORS AND ACTUATORS B-CHEMICAL, 2003, 89 (03) :315-323
[8]   Paper-based microfluidic devices for analysis of clinically relevant analytes present in urine and saliva [J].
Klasner, Scott A. ;
Price, Alexander K. ;
Hoeman, Kurt W. ;
Wilson, Rashaun S. ;
Bell, Kayla J. ;
Culbertson, Christopher T. .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 397 (05) :1821-1829
[9]   Progress in patterned paper sizing for fabrication of paper-based microfluidic sensors [J].
Li, Xu ;
Tian, Junfei ;
Shen, Wei .
CELLULOSE, 2010, 17 (03) :649-659
[10]   Fabrication of paper-based microfluidic sensors by printing [J].
Li, Xu ;
Tian, Junfei ;
Garnier, Gil ;
Shen, Wei .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2010, 76 (02) :564-570