Mental disorders involving antisocial behavior and substance use are genetically linked and vary continuously. The authors present a review and integrative conceptualization of these observations in terms of a dimensional and hierarchically organized externalizing spectrum. As a foundation for this conceptualization, the authors introduce a quantitative, model-based approach to comparing categorical and continuous conceptions of psychopathology and apply this approach in an empirical study of patterns of comorbidity among externalizing disorders as defined in the Diagnostic and Statistical Manual of Mental Disorders. The authors present evidence that comorbidity among externalizing disorders is best modeled by an underlying normally distributed continuum of risk for multiple disorders within the externalizing spectrum. The authors conclude by discussing implications of the externalizing spectrum conceptualization for classification of disorders in the upcoming 5th edition of the Diagnostic and Statistical Manual of Mental Disorders.
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Caspi, A
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McClay, J
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机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
McClay, J
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Moffitt, TE
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机构:
Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, EnglandKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Moffitt, TE
;
Mill, J
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机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Mill, J
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Martin, J
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机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Martin, J
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Craig, IW
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机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Craig, IW
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Taylor, A
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机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Taylor, A
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Poulton, R
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机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
机构:
Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, Pittsburgh Adolescent Alcohol Res Ctr, Pittsburgh, PA 15213 USAUniv Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, Pittsburgh Adolescent Alcohol Res Ctr, Pittsburgh, PA 15213 USA
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Caspi, A
;
McClay, J
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
McClay, J
;
Moffitt, TE
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, EnglandKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Moffitt, TE
;
Mill, J
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Mill, J
;
Martin, J
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Martin, J
;
Craig, IW
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Craig, IW
;
Taylor, A
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
Taylor, A
;
Poulton, R
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England
机构:
Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, Pittsburgh Adolescent Alcohol Res Ctr, Pittsburgh, PA 15213 USAUniv Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, Pittsburgh Adolescent Alcohol Res Ctr, Pittsburgh, PA 15213 USA