Echocardiographic characterization of the cardiovascular phenotype in rodent models

被引：12

作者：

Hoit, BD

机构：

[1] Case Western Reserve Univ, Cleveland, OH 44106 USA

[2] Univ Hosp Cleveland, Cleveland, OH 44106 USA

来源：

TOXICOLOGIC PATHOLOGY | 2006年 / 34卷 / 01期

关键词：

color M-mode; rat TEE; MPI; tissue Doppler;

D O I：

10.1080/01926230500369535

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Echocardiographic techniques are commonly utilized to describe the rodent cardiovascular phenotype. These approaches are contrasted with other in vivo methods and are positioned in the assay selection process by a review of studies from our laboratory and others. Although not conventionally considered a biomarker, the technique has the potential to be exploited as a marker of intentional or unanticipated toxic biological effects in the preclinical development of drugs and chemicals.

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收藏

页码：105 / 110

页数：6

相关论文

共 26 条

[1]

Bers D.M., 2001, Excitation-Contraction Coupling and Cardiac Contractile Force, V2th

[2] Feasibility study: Transesophageal echocardiography with a 10F (3.2-mm), multifrequency (5.5-to 10-MHz) ultrasound catheter in a small rabbit model [J].

Bruce, CJ ;

Packer, DL ;

O'Leary, PW ;

Seward, JB .

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 1999, 12 (07) :596-600

[3] Quantitative 3-dimensional echocardiography for accurate and rapid cardiac phenotype characterization in mice [J].

Dawson, D ;

Lygate, CA ;

Saunders, J ;

Schneider, JE ;

Ye, XJ ;

Hulbert, K ;

Noble, JA ;

Neubauer, S .

CIRCULATION, 2004, 110 (12) :1632-1637

[4] Tissue Doppler Imaging differentiates physiological from pathological pressure-overload left ventricular hypertrophy in rats [J].

Derumeaux, G ;

Mulder, P ;

Richard, V ;

Chagraoui, A ;

Nafeh, C ;

Bauer, F ;

Henry, JP ;

Thuillez, C .

CIRCULATION, 2002, 105 (13) :1602-1608

[5] Noninvasive assessment and necropsy validation of changes in left ventricular mass in ascending aortic banded mice [J].

Fard, A ;

Wang, CY ;

Takuma, S ;

Skopicki, HA ;

Pinsky, DJ ;

Di Tullio, MR ;

Homma, S .

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2000, 13 (06) :582-587

[6]

Feigenbaum H, 1994, ECHOCARDIOGRAPHY

[7] An initial application of transesophageal Doppler echocardiography in experimental small animal models [J].

Gao, ZH ;

Li, JH ;

Kehoe, V ;

Davidson, WR ;

Sinoway, L ;

Pu, M .

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2005, 18 (06) :626-631

[8] Color M-mode Doppler flow propagation velocity is a relatively preload-independent index of left ventricular filling [J].

Garcia, MJ ;

Palac, RT ;

Malenka, DJ ;

Terrell, P ;

Plehn, JF .

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 1999, 12 (02) :129-137

[9] Long-term serotonin administration induces heart valve disease in rats [J].

Gustafsson, BI ;

Tommerås, K ;

Nordrum, I ;

Loennechen, JP ;

Brunsvik, A ;

Solligård, E ;

Fossmark, R ;

Bakke, I ;

Syversen, U ;

Waldum, H .

CIRCULATION, 2005, 111 (12) :1517-1522

[10] New approaches to phenotypic analysis in adult mice [J].

Hoit, BD .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2001, 33 (01) :27-35