Echocardiographic characterization of the cardiovascular phenotype in rodent models

被引：12

作者：

Hoit, BD

机构：

[1] Case Western Reserve Univ, Cleveland, OH 44106 USA

[2] Univ Hosp Cleveland, Cleveland, OH 44106 USA

来源：

TOXICOLOGIC PATHOLOGY | 2006年 / 34卷 / 01期

关键词：

color M-mode; rat TEE; MPI; tissue Doppler;

D O I：

10.1080/01926230500369535

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Echocardiographic techniques are commonly utilized to describe the rodent cardiovascular phenotype. These approaches are contrasted with other in vivo methods and are positioned in the assay selection process by a review of studies from our laboratory and others. Although not conventionally considered a biomarker, the technique has the potential to be exploited as a marker of intentional or unanticipated toxic biological effects in the preclinical development of drugs and chemicals.

引用

收藏

页码：105 / 110

页数：6

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