Function of the Evx-2 gene in the morphogenesis of vertebrate limbs

被引：46

作者：

Herault, Y ^{[1
]}

HrabaRenevey, S ^{[1
]}

vanderHoeven, F ^{[1
]}

Duboule, D ^{[1
]}

机构：

[1] UNIV GENEVA,DEPT ZOOL & ANIM BIOL,CH-1211 GENEVA 4,SWITZERLAND

来源：

EMBO JOURNAL | 1996年 / 15卷 / 23期

关键词：

development; digits; even-skipped; gene targeting; genitalia;

D O I：

10.1002/j.1460-2075.1996.tb01062.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vertebrate gene members of the HoxD complex are essential for proper development of the appendicular skeletons, Inactivation of these genes induces severe alterations in the size and number of bony elements, Evx-2, a gene related to the Drosophila even-skipped (eve) gene, is located close to Hoxd-13 and is expressed in limbs like the neighbouring Herd genes. To investigate whether this tight linkage reflects a functional similarity, we produced a null allele of Evx-2. Furthermore, and because Hoxd-13 function is prevalent over that of nearby Herd genes, we generated two different double mutant loci wherein both Evx-2 and Hoxd-13 were inactivated in cis, The analysis of these various genetic configurations revealed the important function of Evx-2 during the development of the autopod as well as its genetic interaction with Hoxd-13, These results show that, in limbs, Evx-2 functions like a Herd gene, A potential evolutionary scenario is discussed, in which Evx-2 was recruited by the HoxD complex in conjunction with the emergence of digits in an ancestral tetrapod.

引用

页码：6727 / 6738

页数：12

共 45 条

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