No association between DCP1 genotype and late-onset Alzheimer disease

被引:19
作者
Buss, S
Müller-Thomsen, T
Hock, C
Alberici, A
Binetti, G
Nitsch, RM
Gal, A
Finckh, U
机构
[1] Univ Hamburg, Klinikum Eppendorf, Inst Human Genet, D-22529 Hamburg, Germany
[2] Univ Hamburg, Hosp Eppendorf, D-20246 Hamburg, Germany
[3] Univ Zurich, Div Psychiat Res, Zurich, Switzerland
[4] Sci Inst Res & Patient Care, Brescia, Italy
来源
AMERICAN JOURNAL OF MEDICAL GENETICS | 2002年 / 114卷 / 04期
关键词
ACE; DCP1; Hardy Weinberg equilibrium; HWE; review;
D O I
10.1002/ajmg.10306
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
In a study of 261 patients with Alzheimer disease (AD) and 306 cognitively normal control subjects from Germany, Switzerland, and Italy, we found no association between genotype counts or allelic frequencies of DCPI, the gene encoding angiotensin-converting enzyme. In accordance with several other studies, our data could not confirm previous association findings. Critical review about all studies available on DCP1 genotyping and AD, age-associated cognitive decline, longevity, and other conditions revealed remarkable inconsistencies. Several studies showed significant deviations of genotype counts from Hardy Weinberg equilibrium (HWE). Deviations from HWE may limit the comparability of study results and require clarification before drawing conclusions with respect to disease risk, health conditions, or longevity in association with DCP1 genotype. (C) 2002 Wiley-Liss, Inc.
引用
收藏
页码:440 / 445
页数:6
相关论文
共 65 条
[21]  
HIXSON JE, 1990, J LIPID RES, V31, P545
[22]   TRANSCRIPTION OF TESTICULAR ANGIOTENSIN-CONVERTING ENZYME (ACE) IS INITIATED WITHIN THE 12TH INTRON OF THE SOMATIC ACE GENE [J].
HOWARD, TE ;
SHAI, SY ;
LANGFORD, KG ;
MARTIN, BM ;
BERNSTEIN, KE .
MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (08) :4294-4302
[23]   Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population [J].
Hu, J ;
Miyatake, F ;
Aizu, Y ;
Nakagawa, H ;
Nakamura, S ;
Tamaoka, A ;
Takahash, R ;
Urakami, K ;
Shoji, M .
NEUROSCIENCE LETTERS, 1999, 277 (01) :65-67
[24]  
HU J, 2001, IN PRESS J BIOL 1016
[25]   ABSENCE OF LINKAGE BETWEEN THE ANGIOTENSIN CONVERTING ENZYME LOCUS AND HUMAN ESSENTIAL-HYPERTENSION [J].
JEUNEMAITRE, X ;
LIFTON, RP ;
HUNT, SC ;
WILLIAMS, RR ;
LALOUEL, JM .
NATURE GENETICS, 1992, 1 (01) :72-75
[26]   Measured haplotype analysis of the angiotensin-I converting enzyme gene [J].
Keavney, B ;
McKenzie, CA ;
Connell, JMC ;
Julier, C ;
Ratcliffe, PJ ;
Sobel, E ;
Lathrop, M ;
Farrall, M .
HUMAN MOLECULAR GENETICS, 1998, 7 (11) :1745-1751
[27]   Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease [J].
Kehoe, PG ;
Russ, C ;
McIlroy, S ;
Williams, H ;
Holmans, P ;
Holmes, C ;
Liolitsa, D ;
Vahidassr, D ;
Powell, J ;
McGleenon, B ;
Liddell, M ;
Plomin, R ;
Dynan, K ;
Williams, N ;
Neal, J ;
Cairns, NJ ;
Wilcock, G ;
Passmore, P ;
Lovestone, S ;
Williams, J ;
Owen, MJ .
NATURE GENETICS, 1999, 21 (01) :71-72
[28]   Physiological non-equivalence of the two isoforms of angiotensin-converting enzyme [J].
Kessler, SP ;
Rowe, TM ;
Gomos, JB ;
Kessler, PM ;
Sen, GC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (34) :26259-26264
[29]  
KOHN KM, 1995, J ANDROL, V16, P259
[30]   MALE-FEMALE DIFFERENCES IN FERTILITY AND BLOOD-PRESSURE IN ACE-DEFICIENT MICE [J].
KREGE, JH ;
JOHN, SWM ;
LANGENBACH, LL ;
HODGIN, JB ;
HAGAMAN, JR ;
BACHMAN, ES ;
JENNETTE, JC ;
OBRIEN, DA ;
SMITHIES, O .
NATURE, 1995, 375 (6527) :146-148