Depeptidization efforts on P3-P′2 α-ketoamide inhibitors of HCVNS3-4A serine protease:: Effect on HCV replicon activity

被引：14

作者：

Bogen, SL ^{[1
]}

Ruan, S ^{[1
]}

Liu, R ^{[1
]}

Agrawal, S ^{[1
]}

Pichardo, J ^{[1
]}

Prongay, A ^{[1
]}

Baroudy, B ^{[1
]}

Saksena, AK ^{[1
]}

Girijavallabhan, V ^{[1
]}

Njoroge, FG ^{[1
]}

机构：

[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.bmcl.2005.12.013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Depeptidization efforts of the P-3-P-2 region of P-3 capped alpha-ketoamide inhibitor of HCV NS3 serine protease I are reported. We clearly established that N-methylation of the P-2 nitrogen and modification of the P-2' carboxylic acid terminus were essential for activity in the replicon assay. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1621 / 1627

页数：7

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