Osteoconductive hydroxyapatite coated PEEK for spinal fusion surgery

被引：100

作者：

Hahn, Byung Dong ^{[1
]}

Park, Dong-Soo

Choi, Jong-Jin

Ryu, Jungho ^{[1
]}

Yoon, Woon-Ha ^{[1
]}

Choi, Joon-Hwan ^{[1
]}

Kim, Jong-Woo ^{[1
]}

Ahn, Cheol-Woo ^{[1
]}

Kim, Hyoun-Ee ^{[2
]}

Yoon, Byung-Ho ^{[3
]}

Jung, In-Kwon ^{[3
]}

机构：

[1] Korea Inst Mat Sci, Funct Ceram Grp, Chang Won 641010, Gyeong Nam, South Korea

[2] Seoul Natl Univ, Sch Mat Sci & Engn, Seoul 151742, South Korea

[3] Gyeonggi R& DB Ctr, GENOSS, Suwon 443270, Gyeonggi Do, South Korea

来源：

APPLIED SURFACE SCIENCE | 2013年 / 283卷

关键词：

PEEK; Hydroxyapatite; Aerosol deposition; Adhesion strength; Biocompatibility; AEROSOL DEPOSITION; INTERBODY FUSION; IN-VITRO; COATINGS; POLYETHERETHERKETONE; PERFORMANCE; TITANIUM; ADHESION; CELLS;

D O I：

10.1016/j.apsusc.2013.05.073

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Polyetheretherketone (PEEK) has attracted much interest as biomaterial for interbody fusion cages due to its similar stiffness to bone and good radio-transparency for post-op visualization. Hydroxyapatite (HA) coating stimulates bone growth to the medical implant. The objective of this work is to make an implant consisting of biocompatible PEEK with an osteoconductive HA surface for spinal or orthopedic applications. Highly dense and well-adhered HA coating was developed on medical-grade PEEK using aerosol deposition (AD) without thermal degradation of the PEEK. The HA coating had a dense microstructure with no cracks or pores, and showed good adhesion to PEEK at adhesion strengths above 14.3 MPa. The crystallinity of the HA coating was remarkably enhanced by hydrothermal annealing as post-deposition heat-treatment. In addition, in vitro and in vivo biocompatibility of PEEK, in terms of cell adhesion morphology, cell proliferation, differentiation, and bone-to-implant contact ratio, were remarkably enhanced by the HA coating through AD. (c) 2013 Elsevier B.V. All rights reserved.

引用

页码：6 / 11

页数：6

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