Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains

被引：18

作者：

Dankwardt, SM ^{[1
]}

Abbot, SC ^{[1
]}

Broka, CA ^{[1
]}

Martin, RL ^{[1
]}

Chan, CS ^{[1
]}

Springman, EB ^{[1
]}

Van Wart, HE ^{[1
]}

Walker, KAM ^{[1
]}

机构：

[1] Roche Biosci, Inflammatory & Viral Dis Unit, Palo Alto, CA 94304 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(02)00117-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Optimization of the amino acid side chain and the N-alkyl group of the sulfonamide of amino acid derived sulfonamide hydroxamates is discussed. The solid-phase synthesis of these potent inhibitors of procollagen C-proteinase (PCP) is presented. In addition. novel carboxylic acid sulfonamides were discovered to be PCP inhibitors. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1233 / 1235

页数：3

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