Mucosal vaccination against bacterial respiratory infections

被引：26

作者：

Baumann, Ulrich ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Pediat Pulmonol & Neonatol, Immunol Unit, D-30625 Hannover, Germany

来源：

EXPERT REVIEW OF VACCINES | 2008年 / 7卷 / 08期

关键词：

adjuvant; Bordetella pertussis; Haemophilus influenzae; Moraxella catarrhalis; mucosa-associated lymphoid tissue; mucosal vaccination; Mycobacterium tuberculosis; nasal vaccination; oral vaccination; Pseudomonas aeroginosa; respiratory infection; Streptococcus pneumoniae;

D O I：

10.1586/14760584.7.8.1257

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mucosal vaccination offers attractive advantages to conventional systemic vaccination, such as higher levels of antibodies and protection at the airway surface. This review gives an overview of recent experimental and clinical data on nasal, oral and sublingual vaccines against bacterial respiratory pathogens, such as Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Moraxella catarrhalis, Bordetella pertussis, Pseudomonas aeruginosa and Mycobacterium tuberculosis. Subsequently, we discuss further vaccine development that opens the focus to clinical use.

引用

页码：1257 / 1276

页数：20

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