Rational design of Salmonella recombinant vaccines

被引：53

作者：

Cheminay, Cedric ^{[2
]}

Hensel, Michael ^{[1
]}

机构：

[1] Univ Klinikum Erlangen, Inst Mikrobiol, D-91054 Erlangen, Germany

[2] LMU Munchen, Inst Immunol, Munich, Germany

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2008年 / 298卷 / 1-2期

关键词：

live attenuated vaccines; Salmonella pathogenesis; recombinant vaccines;

D O I：

10.1016/j.ijmm.2007.08.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Salmonella enterica is an important pathogen of animals and humans causing a variety of infectious diseases. The large number of cases of typhoid fever due to S. enterica serovar Typhi infections gives rise to the continuous need for improved vaccines against this life-threatening infection. However, S. enterica is also an interesting organism to act as a live attenuated carrier for the presentation of recombinant heterologous antigens. Comprehensive experimental studies have been performed and a detailed knowledge of the molecular mechanisms of important virulence factors is available. This allows the rationale design of improved Salmonella carrier strains and the development of novel strategies for the expression and presentation of recombinant antigens. Here, we review recent advances in generation of live attenuated Salmonella vaccines and discuss criteria for expression strategies of heterologous antigens by Salmonella carrier strains. (C) 2007 Elsevier GmbH. All rights reserved.

引用

页码：87 / 98

页数：12

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