Stress-dependent elasticity of composite actin networks as a model for cell behavior

被引：116

作者：

Gardel, ML ^{[1
]}

Nakamura, F

Hartwig, J

Crocker, JC

Stossel, TP

Weitz, DA

机构：

[1] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA

[2] Harvard Univ, DEAS, Cambridge, MA 02138 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Hematol Div, Boston, MA 02115 USA

[4] Univ Penn, Dept Chem & Biomol Engn, Philadelphia, PA 19104 USA

来源：

PHYSICAL REVIEW LETTERS | 2006年 / 96卷 / 08期

关键词：

D O I：

10.1103/PhysRevLett.96.088102

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Networks of filamentous actin cross-linked with the actin-binding protein filamin A exhibit remarkable strain stiffening leading to an increase in differential elastic modulus by several orders of magnitude over the linear value. The variation of the frequency dependence of the differential elastic and loss moduli as a function of prestress is consistent with that observed in living cells, suggesting that cell elasticity is always measured in the nonlinear regime, and that prestress is an essential control parameter.

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页数：4

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