Parallel Synthesis of a Multi-Substituted Benzo[b]furan Library

被引：65

作者：

Cho, Chul-Hee ^{[1
]}

Neuenswander, Benjamin ^{[2
,3
]}

Lushington, Gerald H. ^{[2
,3
]}

Larock, Richard C. ^{[1
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

[2] Univ Kansas, NIH, Ctr Excellence Chem Methodol, Lawrence, KS 66047 USA

[3] Univ Kansas, NIH, Lib Dev, Lawrence, KS 66047 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2008年 / 10卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1021/cc800120y

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The solution-phase parallel synthesis of a 121-member library of multi-substituted benzo[b]furans is described. 2.3,5-Trisubstituted benzo[b]furans have been prepared by the palladium-catalyzed substitution of 3-iodobenzofurans by Suzuki-Miyaura, carbonylative Suzuki, Sonogashira, Heck, and carboalkoxylation chemistry. The 3-iodobenzofurans are readily prepared in good to excellent yields by the palladium/copper-catalyzed cross-coupling of various o-iodoanisoles and terminal alkynes, followed by electrophilic cyclization with ICI.

引用

收藏

页码：941 / 947

页数：7

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